Fungus study reveals how a histone mark switches on a key antioxidant enzyme
Researchers report that loss of the SET-1-mediated H3K4me3 histone mark in Neurospora crassa lowers catalase-3 expression and increases hydrogen peroxide ...
Tag: RNA polymerase II
Scientists Watch RNA-Binding Proteins Assemble on Nascent Transcripts in Real Time
Fluorescent tagging in living cells reveals the ordered recruitment of RNA-binding proteins to nascent intronless transcripts, including a temporal gap ...
Cancer cells ramp up transcription across the genome, review finds
A new review describes how global transcriptional upregulation, or hypertranscription, driven by oncogene-encoded transcription factors may contribute to chromosomal instability ...
FBXO28 ubiquitinates BRD4 to fuel lung cancer cell malignancy
A study in non-small cell lung cancer models found that FBXO28 promotes proliferation, migration and invasion by ubiquitinating BRD4 and ...
Low Oxygen Helps Early Embryos Switch On Their Genes, Mouse Study Finds
A new mouse study shows that hypoxic culture enhances zygotic genome activation by increasing H3K4me3 at zygotic gene promoters and ...
Super Elongation Complex Found to Switch On Genes That Transform Cell Identity
New research shows that the Super Elongation Complex drives both stem cell reprogramming and neural differentiation by releasing paused RNA ...
Gene Activity Comes in Bursts: Epigenetics Reshapes the Picture of Transcriptional Noise
A new review argues that transcription occurs in multi-scale bursts shaped by DNA methylation, histone variants, modifications and enhancer looping, ...
Revealing RNA Polymerase II Start Sites via csRNA-seq
In a groundbreaking development in the field of molecular biology, researchers have introduced a comprehensive and efficient methodology for analyzing ...
CFAP20 Rescues Stalled RNAPII During Replication
In a groundbreaking study published in Nature, researchers have uncovered a surprising role for the protein CFAP20, a molecule previously ...
Transcription-Coupled Repair: Guardians of DNA Integrity
Transcription is a vital cellular process orchestrated by RNA polymerase II (Pol II), enabling the expression of genes that drive ...
