The Left Atrium May Hold the Key to Feline Heart Disease Outcomes
A new review argues that the left atrium, not the ventricle, drives the clinical outcomes of feline hypertrophic cardiomyopathy and ...
Tag: Rapamycin
Isoleucine and Valine, Not Leucine, Drive T Cell Proliferation Through c-Myc
A mouse study finds that isoleucine and valine, rather than leucine, sustain c-Myc expression and proliferation in activated CD8 T ...
Collagen-Coated Rapamycin Liposomes Show Cartilage Repair Promise in Rats
A collagen-coated rapamycin liposome system preserved cartilage structure and showed no organ toxicity in a rat model of osteoarthritis.
Multi-omics study links autophagy and ER stress to PFOA toxicity in sperm precursor cells
A multi-omics study in GC-1 spermatogonial cells links PFOA exposure to altered autophagy, ER stress signaling and oxidative imbalance, with ...
mTORC1 may act as a transition switch in ME/CFS post-exertional malaise
A new review proposes mTORC1 as a transition switch linking mitochondrial dysfunction to post-exertional malaise in ME/CFS, while noting that ...
Same Drug, Different Cells: Why mTOR Inhibition in Plaques Defies Simple Rules
A new review argues that mTOR's effects in atherosclerotic plaques depend on cell state, plaque niche, signalling complex and drug ...
Mouse aging-rate indicators could speed anti-aging drug screening
A systematic review of mouse longevity studies proposes 12 experimental aging rate indicators that could accelerate early screening of anti-aging ...
UV radiation boosts ribosome production in Fusarium mangiferae filaments
In the plant pathogen Fusarium mangiferae, ultraviolet C radiation significantly increases ribosome levels and translation capacity in filaments, and blocking ...
Scientists Uncover Hidden Protein Driver Behind Scarring Kidney Disease
New research reveals that the protein Annexin A1 drives kidney fibrosis by activating YAP signaling and suppressing autophagy in renal ...
Jonathan the 194-Year-Old Tortoise Reveals a Genetic Secret to Aging Slowly
A Vanderbilt-led team sequencing the genome and epigenome of Jonathan, a 194-year-old giant tortoise on St. Helena, found that promoters ...
Zebrafish Reveal a Surprising Trick for Rebuilding Nerves: Letting Dendrites Go First
New research in adult zebrafish shows that transient dendritic pruning driven by repressed mTORC1 signaling is essential for efficient axonal ...
Why Extending Healthspan Without Lifespan Is a Misguided Goal for Aging Science
Researchers argue that the popular slogan of extending healthspan but not lifespan is scientifically incoherent and ethically untenable as a ...
Cellular Recycling Machine Linked to Male Fertility Hormone Control
New research reveals that the cellular recycling protein p97/VCP directly regulates the autophagic degradation of androgen-binding protein in Sertoli cells, ...
Aging Makes Fatty Chains Longer, and Shortening Them Extends Lifespan
A cross-species study in Nature Aging shows that lipid acyl chains lengthen consistently with age across mice, worms, flies and ...
Dogs Reveal Sex-Specific Immune Aging Patterns and Early Clues on Anti-Aging Drugs
A controlled study of 80 Beagles maps non-linear, sex-stratified immune aging across the canine lifespan and finds exploratory evidence that ...
Rapamycin’s Promise Could It Delay Menopause
Menopause, that long-overlooked life transition once brushed aside as a foregone conclusion of aging, has quietly become a focal point ...
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