TERRA R-loops turn chromosome ends into cancer’s weak spot
A new review explains how TERRA-driven R-loops at telomeres can either protect chromosome ends or fuel replication stress, genomic instability ...
Tag: R-loops
Bone-aging study links R-loop buildup to osteoblast DNA damage
A new study in Cell Death Discovery shows that the PRMT6–SIRT5–HADHA pathway protects bone-forming osteoblasts from R-loop-induced DNA damage during ...
RNA Chaperone ALYREF Hijacks Poly-ADP-Ribose at DNA Breaks and Slows Repair in Tumor Cells
Researchers report that the RNA-processing protein ALYREF binds poly-ADP-ribose at DNA double-strand breaks, delaying repair when overexpressed and marking a ...
Machine Learning Maps R-Loop Scores to NCL-Driven Malignant Progression in Colorectal Cancer
A consensus machine learning approach integrating single-cell and spatial transcriptomics identifies nucleolin (NCL) as a functional marker of R-loop-associated malignant ...
R-Loop Gene Signature Predicts Survival and Immune Landscape in Esophageal Cancer
Researchers have built the first R-loop-related gene signature for esophageal squamous cell carcinoma, identifying BRIX1, CHEK1, and NUP155 as core ...
R-Loops: Double-Edged Players in Genome Stability and Disease
In the rapidly evolving landscape of molecular biology, R-loops—a three-stranded nucleic acid structure formed by an RNA:DNA hybrid and a ...
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