Leukemia That Refuses to Choose: The Science of Mixed Phenotype Acute Leukemia
A new review in Cancer Cell International synthesizes contemporary classification, clonal biology, and precision therapy for mixed phenotype acute leukemia, ...
Tag: Precision Medicine
Vitamin D Levels and Receptor Gene Variants Combine to Drive Kidney Stone Risk
A new case-control study from a genetically homogeneous population in India reveals that elevated serum vitamin D and specific vitamin ...
Protein Clues Reveal Why Heart Risk Lingers After Bad Cholesterol Falls
A large Swedish proteomics study of nearly 3,000 blood proteins in 35,000 UK Biobank participants reveals how triglyceride-rich lipoproteins and ...
Three-Day Whole Genome Sequencing Transforms Childhood Cancer Diagnosis
A UK study shows rapid whole genome sequencing cuts pediatric cancer diagnosis time from six weeks to three days while ...
Hidden Causes of High Blood Pressure: New Review Maps Precision Path to Cure
A systematic evidence review finds that secondary hypertension remains vastly under-screened despite mechanism-based diagnostic tests and, for several causes, potentially ...
Barcoded organoid pools test cancer drugs in one dish
A clonal DNA barcoding platform pools organoids from many colorectal cancer patients in one dish, tracking drug sensitivity through barcode ...
AI aging clocks: how machines learn to measure how fast you are really aging
A major new review maps how artificial intelligence is transforming biological age prediction, from epigenetic clocks to multimodal deep learning, ...
Chemotherapy Wrecks the Bone Marrow Ecosystem, Not Just Platelet Counts, Review Argues
A new review in Supportive Care in Cancer reframes chemotherapy-induced thrombocytopenia as a dual destruction of megakaryocytes and the bone ...
Genes May Decide How Well Your Diabetes Drugs Work, Review Finds
A new integrative review synthesizes 31 human studies showing how transporter, enzyme and target gene variants shape individual responses to ...
From cooperation to collapse: the diet-microbiota-host gene triad in disease and aging
A new review in Frontiers in Microbiomes argues that aging and disease reflect the collapse of an ancient symbiotic network ...
Black Race Found to Be Strongest Predictor of Severe Type 2-High Asthma in Children
The distinction between T2-high and T2-low asthma represents one of the most consequential shifts in modern respiratory medicine. Type 2 ...
New AI Framework Maps Drug Sensitivity Down to Individual Cells in Bulk Tumor Samples
A new two-step machine-learning framework called CLIMB and CLIFF computationally deconvolves bulk RNA-seq and drug sensitivity data into cell-type and ...
Pharmacoepigenetics: How Epigenetic Regulation Is Driving Personalized Therapeutics
A new Frontiers in Pharmacology review maps how epigenetic regulation shapes drug response and how FDA-approved and emerging epigenetic therapies ...
Single-Cell Sequencing Reveals Why Diabetic Foot Ulcers Refuse to Heal
A new review details how single-cell RNA sequencing is exposing the cellular and molecular failures that keep diabetic foot ulcers ...
Machine Learning Is Rewriting the Design of Implantable Drug Delivery Systems
A new review details how machine learning is accelerating the design of implantable drug delivery systems, from ocular and cochlear ...
When One Gene Means Many Diseases: Multi-Disorder Genes Drive Lab Disagreement on Variant Pathogenicity
A national study of 128 clinical genetics laboratories finds that variants in multi-disease genes such as APOB, LZTR1, MYH7, and ...
How Menopause Reshapes Gut Microbes That Influence How Drugs Work
A new review argues that menopause-driven gut microbiome changes may reshape drug metabolism and explain variability in medication response among ...
Targeting gut dysbiosis: a new frontier in MASLD management
Metabolic dysfunction-associated steatotic liver disease, known as MASLD, has quietly become the most common chronic liver condition on the planet, ...
3D Facial Scans Could Turn Swelling Into an Objective Biomarker for a Rare Disease
For people living with rare diseases, the road to a diagnosis is often measured in years. More than 10,000 distinct ...
AI and Multi-Omics Converge to Decode the Hidden Language of the Human Microbiome
A landmark review reveals how artificial intelligence and integrative multi-omics are transforming host-microbiome research, converting complex molecular data into predictive ...
