Genes May Not Predict COPD Inhaler Response, Systematic Review Finds
A systematic review of eight studies finds that genetic variants show inconsistent and largely unreplicated associations with how COPD patients ...
Tag: Pharmacogenetics
Research report: Integrating inheritance model selection, weighted polygenic scoring, and interpretable machine learning for cardiotoxicity risk prediction in pediatric ALL
In 216 Pakistani children with ALL, a weighted five-variant polygenic score discriminated anthracycline-induced cardiotoxicity far better than an unweighted score, ...
Common antibiotic can trigger permanent hearing loss in babies carrying one mitochondrial mutation
An integrative review finds the m.1555A>G mitochondrial variant in roughly 1 in 500 newborns and links aminoglycoside exposure to failed ...
Targeted sequencing finds frequent TB and NTM co-detection in Chinese cohort
Targeted sequencing of 83 respiratory specimens in Jiangxi, China, found MTC/NTM co-detection in about a quarter of patients and genotypically ...
Exome and Array Data Combined Rival Whole-Genome Sequencing for Most Pharmacogenes
Combining whole-exome sequencing with imputed genotyping array data matched whole-genome sequencing results for 25 of 33 pharmacogenes in UK Biobank ...
Research report: Estimating metabolic pathway overlap in precision oncology: integrating pharmacogenetics and polypharmacy
Only a small fraction of the drugs recommended for gastrointestinal cancers are directly steered by known pharmacogenetic variants, yet the ...
Retrospective Henan tuberculosis cohort finds no significant link between slow NAT2 acetylation and new liver abnormalities
A retrospective single-center study of 801 patients with tuberculosis in Henan Province found no statistically significant association between slow NAT2 ...
Hidden Gene Variants May Explain Why Chemotherapy Hits Some Patients Harder Than Others
A new review links inherited variants in ABCB1, ABCC1, and ABCG2 drug transporter genes to differences in chemotherapy and targeted ...
Genes May Decide How Well Your Diabetes Drugs Work, Review Finds
A new integrative review synthesizes 31 human studies showing how transporter, enzyme and target gene variants shape individual responses to ...
CYP2C9 & CYP2C19 Impact on CBD Metabolism
In a groundbreaking study poised to reshape our understanding of cannabis consumption and metabolism, researchers have unveiled the pivotal role ...
POPULAR NEWS
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Case Report Explores Caplacizumab in Late-Diagnosed Congenital Thrombotic Thrombocytopenic Purpura
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Multitask Cambrian Model Improves Protein Melting Temperature Prediction
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Vasopressors Exert Divergent Immunomodulatory Effects Across a Spectrum in Septic Shock
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Study Identifies Key Drivers Shaping Salmonid Gill Microbiomes in Aquaculture