Cardiac Stem Cells Show Promise but Cardiomyocyte Potential Remains Contested
A new review in Biological Research surveys cardiac stem and progenitor cell populations, finding that classic markers c-kit and Sca-1 ...
Tag: paracrine signaling
PTN-Secreting Glioblastoma Subclone Rebuilds the Immune Niche to Seed Distant Recurrence
Single-cell sequencing and mouse experiments show that PTN-positive glioblastoma cells recruit anti-inflammatory macrophages through a PTN-NCL interaction, creating the immune ...
St. John’s Wort Alters Microglia-Neuron Signals in Cell Culture
A mouse-cell co-culture study found that St. John’s wort altered neuron-microglia signaling, neurite outgrowth and release of CDF/LIF and GDF-15, ...
Circadian-Linked Endothelial State Offers New Clue to Stroke Recovery
A newly identified PI16-expressing reactive endothelial cell state with strong circadian gene activity supports neuronal survival and reduces brain injury ...
Heart Muscle Cells Signal Their Own Maturation Through TGFβ, Mouse Study Finds
Deleting TGFβ ligands in developing mouse cardiomyocytes disrupts heart maturation and triggers ectopic skeletal muscle gene expression, revealing a paracrine ...
Hidden Cell-to-Cell Messaging Networks Drive Triple-Negative Breast Cancer Resistance
A new review argues that triple-negative breast cancer's heterogeneity and therapy resistance emerge from spatially organized paracrine signaling networks between ...
SPP1 Crucial for Pancreatic Cancer Cell Fate
In a groundbreaking study published in Nature, researchers have unraveled a crucial cellular dialogue that sustains pancreatic ductal adenocarcinoma (PDAC), ...
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