Tag: Ovarian cancer

A single-cell transcriptomics study reveals that conserved fallopian tube epithelial programs drive chemoresistance and treatment response heterogeneity in ovarian high-grade ...

A new commentary argues that a recent study on breast cancer prevention in BRCA-mutated ovarian cancer patients suffers from survivorship ...

A phase 2 trial found that adding immunotherapy to chemotherapy did not improve the primary efficacy endpoint in advanced ovarian ...

A combined analysis of global disease data and Mendelian randomization identifies lipid species and immune traits with putative causal links ...

Researchers report that stromal APOL4 marks a distinct cancer-associated fibroblast state whose loss confers carboplatin resistance in ovarian cancer co-cultures ...

A prospective imaging study of eleven patients with five different cancers found that I-PARPi SPECT/CT uptake corresponded with PARP immunohistochemistry ...

Cysteine-Rich Protein 1 (CRIP1) expression is significantly upregulated in ovarian cancer tissues compared to adjacent normal tissues, and high expression ...

A five-gene machine-learning signature predicts ovarian cancer survival, and the core gene ACSM3 acts as a tumor suppressor by limiting ...

A preclinical study reports that the Notch ligand DLL1 activates an Nrf2/GPX4 antioxidant axis that suppresses ferroptosis and weakens cisplatin's ...

A first-in-human Phase 1/2a trial of the B7-H4-targeting antibody-drug conjugate puxitatug samrotecan reported partial responses in heavily pretreated ovarian, endometrial ...

A Hamburg registry study of 576 advanced ovarian cancer patients found that complete surgical clearance was associated with lower mortality ...

A re-analysis of prostate cancer reporter assay data shows computational annotations poorly predict measured regulatory activity, while ovarian risk variant ...

Healthy women carrying pathogenic BRCA1 or BRCA2 variants have significantly fewer hypomethylated, presumably active ribosomal DNA copies in their blood ...

Preclinical experiments show that depriving ovarian cancer cells of cyst(e)ine, or blocking its metabolism with drugs, enhances their responsiveness to ...

A retrospective single-center study of 148 patients found that two-thirds of women with germline BRCA-mutated breast cancer underwent risk-reducing salpingo-oophorectomy, ...

A screen of over 1400 FDA-approved compounds identified topoisomerase I inhibitors as the most effective partners for PARP inhibitors in ...

A ROS-responsive nanoparticle co-delivering a PARP inhibitor prodrug and a DOT1L inhibitor amplified DNA damage, activated cGAS-STING signaling and improved ...

A new review finds that ACSL4 currently has the strongest disease-specific evidence among long-chain acyl-CoA synthetases across six female reproductive ...

A new Cellular Oncology study reports that the tumor suppressor TNFAIP3 restrains lactylation-linked DNA damage repair and increases ovarian cancer ...

A new study in Clinical and Experimental Medicine reports that ANGPTL4 promotes ovarian cancer invasion and angiogenesis through an Integrin ...