Tumor Protein S100A9 Drives Skeletal Muscle Wasting in Neuroblastoma Mouse Models
A study in mice, cultured cells, and pediatric patients reveals that the tumor-secreted protein S100A9 triggers neuroblastoma-associated skeletal muscle atrophy ...
Tag: O-GlcNAcylation
Gut Bacterium Drives Breast Cancer via Enzyme Pathway
A Foshan-based team identifies Ruminococcus lactaris as a gut bacterium that drives breast cancer progression and chemotherapy resistance via a ...
How HPV rewires sugar chemistry in cervical cancer cells
A new review finds that O-GlcNAcylation links HPV-driven metabolic demand to growth and survival pathways in cervical cancer, but no ...
Sugar Tag on ASGR1 Protein Curbs Deadly Heart Damage in Sepsis
A sugar modification of the ASGR1 protein reduces septic heart injury in mice by blocking ZBP1-driven PANoptosis, according to a ...
PLK1’s Hidden Code: How Chemical Tags Orchestrate Cell Division and Cancer
A new review synthesizes how phosphorylation, ubiquitination, methylation, SUMOylation and O-GlcNAcylation form an interconnected network that controls the mitotic kinase ...
Metabolic Protein Tags Emerge as Key Players in Disc Degeneration
A new review maps how metabolite-driven protein modifications such as lactylation, O-GlcNAcylation and succinylation may link the disc's harsh metabolic ...
GFPT1 silencing curbs aggressive esophageal cancer cell behavior through ER stress
Cell experiments found that silencing GFPT1 reduced proliferation, migration and invasion in esophageal cancer cells, with a rescue experiment supporting ...
Sugar Coats on Death Receptors Act as Molecular Switches Deciding Cell Fate
A new review reveals that sugar chains attached to death receptors act as molecular checkpoints that determine whether cells undergo ...
Hidden Protein Switches That Keep Bones in Balance May Reshape Osteoporosis Research
A new BMC Medicine review maps how post-translational modifications act as a networked control layer that gates, amplifies, and dampens ...
GlcNAcylation Enhances H2BK120 Monoubiquitylation Process
In a groundbreaking study, researchers have delved into the intricate mechanisms of transcriptional regulation facilitated by the modification of histones, ...
