Single-Cell Atlas Reveals DLL3 as a Drug Target in Aggressive Cervical Cancer
A single-cell multi-omic atlas of neuroendocrine carcinoma of the cervix identifies DLL3 as a driver of immune evasion and validates ...
Tag: Notch Signaling
How Cancer-Causing Viruses Hijack the Notch Signaling Pathway
A new review details how six major human oncoviruses dysregulate the Notch signaling pathway to drive proliferation, apoptosis resistance, and ...
Exploding immune cells may explain why prostate drug therapy fails in some men
A new study shows that 5-alpha-reductase inhibitor therapy can trigger macrophage pyroptosis, HMGB1–AGER-driven epithelial senescence and club-cell reprogramming in the ...
New Spatial Transcriptomics Tool Maps Gene Expression Across Tissue Boundaries in the Developing Mouse Brain
Researchers have developed REBOSEP, a computational workflow that maps gene expression as a continuous signal across tissue boundaries and reveals ...
New Wave of Targeted and Immune Therapies Reshapes Marginal Zone Lymphoma Care
A new review in Annals of Hematology details how molecular profiling and a growing arsenal of targeted and immune-based therapies ...
The Hidden RNA Master Switch That Behaves Differently in Every Cancer
A new review reveals how the long non-coding RNA MIR99AHG acts as a multifunctional host gene and regulatory hub whose ...
Impact of Patient Variability on Vascular Tissue Engineering
Emerging research in the realm of biomedicine is forging a new path in the field of vascular tissue engineering. The ...
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