Tag: NLRP3 inflammasome

A newly identified protein circuit in macrophages controls inflammatory kidney damage, and a natural compound can restore it.

New research reveals that hydrogen sulfide protects against diabetic vascular damage by modifying thioredoxin reductase 1, thereby suppressing inflammatory pathways ...

A new review argues that mitochondrial dysfunction is the central mechanism linking metabolic stress, inflammation, and nerve degeneration in diabetic ...

Researchers at Sun Yat-sen University show that blocking the cGAS-STING pathway and the NLRP3 inflammasome reduces inflammatory cell death and ...

Age-related hearing loss, or presbycusis, has long been viewed as an inevitable consequence of wear and tear on the delicate ...

A new comprehensive review maps the signaling pathways, biomarkers, and molecular signatures that determine whether heart muscle survives ischemic injury.

Scientists engineered a probiotic bacterium that produces the anti-inflammatory lipid palmitoylethanolamide directly in the gut, protecting mice with chronic colitis ...

A new review proposes that electroacupuncture may ease long COVID by activating vagal cholinergic anti-inflammatory signaling and restoring mitochondrial metabolic ...

A new review argues that ferroptosis and pyroptosis may converge to drive necrotizing enterocolitis in preterm infants, and that biomarker-guided ...

A combined bioinformatics and molecular simulation study identifies MMP1 as a shared hub gene and colchicine target linking gout and ...

A small retrospective study finds that high-dose colchicine was associated with significantly lower ferritin levels and a trend toward reduced ...

A multi-omics study in rats reveals that permanent middle cerebral artery occlusion remodels cecal microbiota and drives a lipid-centered inflammatory ...

A new hypothesis-driven framework proposes that metabolic syndrome may prime the brain's immune cells through trained-immunity-like mechanisms and weaken parvalbumin ...

A new study identifies CYLD as a deubiquitinase that stabilizes microglial IKKβ, driving NF-κB–NLRP3 signaling, neuronal pyroptosis, and cognitive decline ...

A Chilean-led study shows the boldo-derived alkaloid boldine blocks large-pore channels in muscle cells, preventing diabetes-induced muscle weakness, lipid accumulation ...

A new narrative review maps the complex, context-dependent crosstalk between neurotransmitter systems and the NLRP3 inflammasome, revealing bidirectional regulation with ...

A new review in the Journal of Ovarian Research argues that age-related shifts in ovarian macrophages, driven by pathways such ...

A new review argues that the phosphorylation-dephosphorylation balance controlled largely by the phosphatase PP2Acα acts as a master switch in ...

A new review argues that oxidized mitochondrial DNA acts as both a persistent inflammatory signal and a potential biomarker driving ...

New research in the British Journal of Cancer shows that oxygen-starved oral cancer cells activate an HMGB1-driven NLRP3 inflammasome pathway ...