AI in MS, NMOSD, autoimmune encephalitis and MOGAD: promise still outruns proof
A new review finds AI applications in CNS autoimmune diseases are expanding rapidly, yet no model has been prospectively validated ...
Tag: Multiple Sclerosis
Blocking Two Opposing Signals Steers Repair Cells Back to Rebuilding Myelin in Mice
In a mouse model of demyelination, OPCs shift toward an astrocyte-like state through opposing BMP and Wnt signaling, and blocking ...
Monocytes, Not T Cells, Show Strongest Gene Disruption in Multiple Sclerosis
A reanalysis of bulk RNA-sequencing data from multiple sclerosis patients finds that CD14+ monocytes show the most extensive transcriptional and ...
CSF Study Reveals Distinct Cytokine and Complement Signatures in NMOSD, MOGAD, and MS
A Johns Hopkins study of spinal fluid from patients with AQP4+ NMOSD, MOGAD, and MS found distinct cytokine profiles and ...
Mitochondrial dysfunction emerges as a shared thread across neurological disease
A new review in Nature Reviews Neurology outlines how mitochondrial biomarkers spanning fluid, genetic, multi-omics and imaging domains could aid ...
Chronic Demyelination Traps Microglia in a Lysosomal Cholesterol State
A Nature Neuroscience study in mouse models and human multiple sclerosis tissue identifies a pro-inflammatory microglial state marked by lysosomal ...
Freezing Shifts Serum Neurofilament Light Chain Results Differently Across Four Immunoassays
A paired-sample study of 20 multiple sclerosis patients found that freezing changed serum neurofilament light chain measurements by different amounts ...
Gut bacterium Faecalibacterium prausnitzii emerges as candidate probiotic for neurological disorders
A new review consolidates evidence that the butyrate-producing gut bacterium Faecalibacterium prausnitzii is depleted across several neurological disorders and shows ...
MRI Activity Drives Early High-Efficacy Treatment Choices in Multiple Sclerosis
A French Delphi study found that MRI evidence of high activity most consistently led neurologists to recommend early monoclonal high-efficacy ...
Danish registry study links cladribine to lower short-term MS relapse rates
A Danish nationwide registry study found lower short-term relapse rates and few confirmed disability-worsening events among people with relapsing–remitting multiple ...
Systematic assessment finds confounding gap in multiple sclerosis trial emulations
A systematic assessment identified 160 potential confounders for target trial emulation in relapsing-remitting multiple sclerosis, revealing substantial gaps between clinical ...
Incident Diabetes Linked to More Hospitalisations and Death in Multiple Sclerosis
An English population-based cohort study found that incident diabetes was associated with more hospitalisations, longer stays and higher mortality among ...
Lower vision-related quality of life linked to depressive symptoms in MS and NMOSD
A multicenter cross-sectional study of 458 adults with multiple sclerosis or neuromyelitis optica spectrum disorder found that lower vision-related quality ...
Automated MS imaging finds microstructural complexity beyond lesion burden
In a 100-person multiple sclerosis imaging cohort, an automated lesion-segmentation and diffusion-tensor pipeline found that reference-like white matter within lesions ...
Tiny Brain Vesicles in Blood Could Transform Diagnosis of Neurological Disease
A new review details how extracellular vesicles carrying brain-derived proteins and RNAs could enable minimally invasive diagnosis of Alzheimer's, Parkinson's, ...
Most Bulgarian Patients With Chronic Pain and Neurodegenerative Disease Would Try CBD If Doctors Recommended It
A survey of 55 Bulgarian patients found that 85.5 percent would use cannabidiol if recommended by a healthcare professional, despite ...
Fatigue relief is possible
A new review finds that cognitive behavioral therapy, mindfulness, yoga, and physical activity consistently relieve chronic fatigue across stroke, cancer, ...
GLP-1 Drugs Like Ozempic Face a New Test: Multiple Sclerosis
A new narrative review finds that GLP-1 receptor agonists like semaglutide and tirzepatide are safe and effective for weight loss ...
Brain Volumetry Pipelines Are Not Interchangeable, Landmark Comparison Reveals
A head-to-head comparison of six established brain segmentation pipelines across healthy controls, multiple sclerosis, and Alzheimer's disease finds systematic volume ...
BTK Inhibitor Ibrutinib Speeds Remyelination via Reprogrammed Microglial Vesicles
New research shows the BTK inhibitor ibrutinib accelerates remyelination by reprogramming microglial extracellular vesicles to carry the repair-promoting microRNA miR-223.
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