Rapid Relapse Marks a Distinct, High-Risk Group in Triple-Negative Breast Cancer
A Swedish nationwide registry study of 8,298 triple-negative breast cancer patients finds that relapse or death within 24 months defines ...
Tag: Metastasis
Circulating tumor cells reveal immune escape tricks that may guide immunotherapy
A new review maps how circulating tumor cells survive immune attack in the bloodstream and outlines what evidence is still ...
Cell adhesion molecule VCAM-1 drives colorectal cancer spread through cytoskeletal pathway
A new study links VCAM-1 to colorectal cancer growth and spread through the RhoA/LIMK/Cofilin cytoskeletal pathway, while its survival association ...
Heat Shock Proteins Shape Cancer Growth and Treatment Resistance
A review describes how heat shock proteins influence tumor survival, metastasis, immune escape, and the design of future targeted cancer ...
Study Identifies ANGPTL4 Signaling Axis Driving Ovarian Cancer Invasion and Angiogenesis
A new study in Clinical and Experimental Medicine reports that ANGPTL4 promotes ovarian cancer invasion and angiogenesis through an Integrin ...
DNA Methylation of Two Long Non-Coding RNA Loci Tracks Metastatic Disease in Kidney Cancer
DNA methylation at the LINC01354 and LINC01510 long non-coding RNA loci rises with tumor stage, grade and metastatic spread in ...
Machine Learning Model Links Tumor Cell Malignancy to Osteosarcoma Outcomes and Flags OPN3 as a Drug Target Candidate
A machine learning model built from single-cell data stratifies osteosarcoma patients by survival risk and identifies OPN3 as a candidate ...
PLPP4 marks a fibroblast subset that fuels tumor growth through excess matrix deposition
Researchers identified PLPP4 as a functional marker of an ECM-enriched cancer-associated fibroblast subset that promotes tumor growth and metastasis via ...
Rapid autopsy maps lethal bladder cancer evolution in 20 patients
A rapid-autopsy study of 104 tumors from 20 patients found that metastatic bladder tumors appeared to seed further spread and ...
SP1-induced PDRG1 drives hepatocellular carcinoma growth via Wnt/β-catenin signaling
An experimental study reports that SP1-induced PDRG1 promotes the proliferation and metastasis of hepatocellular carcinoma by activating the Wnt/β-catenin pathway ...
Collagen-Targeted MRI Agent Spots Tiny Lung Tumors and Hidden Metastases in Preclinical Tests
A collagen-targeted protein MRI contrast agent developed at Georgia State University detected invasive lung tumors and multi-organ metastases as small ...
Calcium Switches Mitochondrial Motors to Drive Filopodia and Cell Migration
In A431 carcinoma cells, EGF-driven calcium signaling shifts mitochondrial trafficking from the kinesin Kif5B to the actin-based motor Myo19, delivering ...
Observational genome study links eight processes to most prostate cancer DNA damage
An observational analysis of 959 prostate tumours from 1,001 men found that eight cellular processes account for 85% of DNA ...
HOTAIR functions as a context-dependent cancer regulator, review finds
A review finds that HOTAIR links chromatin remodeling, tumor progression, metabolic adaptation and treatment resistance through functions that vary by ...
PRKAR2A Emerges as Candidate Spatial cAMP–PKA Router in TNBC
A critical review finds that PRKAR2A is a plausible spatial regulator of cAMP–PKA signalling in triple-negative breast cancer, although current ...
How a high-fat diet may help colon cancer spread to the liver
MIT biologists have identified a YAP1-driven regenerative pathway, activated by diet-derived ceramides, that colorectal cancer cells hijack to metastasize to ...
Ovarian Cancer Cells Depend on USP15 Enzyme, Offering a Sharper Therapeutic Target
UMBC researchers found that ovarian cancer cells depend heavily on the enzyme USP15, and reducing it slows tumor growth, disrupts ...
Computational Study Links Metabolic Enzyme NNMT to a Triple Shield That Lets Cancer Cell Clusters Survive in the Bloodstream
A new computational framework links the metabolic enzyme NNMT to coordinated platelet, neutrophil, and immune exhaustion programs in circulating tumor ...
Severe Pain and Low Opioid Doses Predict Who Responds Best to Nerve Blocks for Cancer Pain
A retrospective study of 349 hospitalized cancer patients found that higher baseline pain intensity and lower opioid doses independently predicted ...
ENO3 Emerges as a Lactate-Linked Biomarker in Colorectal Cancer Metastasis
Integrated transcriptomic analysis of TCGA and GEO datasets identifies a six-gene lactate metabolism signature and nominates ENO3 as a prognosis-associated ...
