Metagenomic Sequencing Identifies Rare Rhizopus Eye Infection Following Plant Trauma
A case report details how metagenomic sequencing identified a rare Rhizopus arrhizus eye infection following plant trauma in an immunocompetent ...
Tag: metagenomic next-generation sequencing
Tissue factor-targeted antibody-drug conjugate linked to severe ocular surface toxicity in five patients
A retrospective case series links a tissue factor-targeted antibody-drug conjugate to severe ocular surface toxicity in five of 116 trial ...
Retrospective Study Examines Tropheryma whipplei Detection in Bronchoalveolar Lavage Fluid
A retrospective cohort study evaluated 74 patients with Tropheryma whipplei detected in bronchoalveolar lavage fluid by metagenomic next-generation sequencing, finding ...
Fatal Pneumocystis pneumonia with rapidly progressive lung disease in anti-MDA5 dermatomyositis
A case report describes a 70-year-old woman with anti-MDA5-positive dermatomyositis who died 13 days after admission despite treatment for Pneumocystis ...
Microbes on orthopaedic implants do not always mean infection, review finds
A structured narrative review argues that microbial signals detected on orthopaedic implants require a three-step interpretation separating analytical credibility, biological ...
Research report: Metagenomic-based quantification of Pseudomonas aeruginosa burden links microbiome collapse to mortality in severe community-acquired pneumonia
A multicenter retrospective study found that higher mNGS-derived Pseudomonas aeruginosa abundance in severe community-acquired pneumonia was associated with lung microbiome ...
Blood mNGS strategies compared head-to-head in suspected sepsis
A prospective study of 121 patients with suspected sepsis compared peripheral blood host depletion mNGS and plasma cell-free DNA mNGS, ...
Rapid Sequencing Outperforms Routine Tests in Detecting Tuberculosis, Study Finds
A retrospective study of 425 patients in China found metagenomic next-generation sequencing detected tuberculosis with 90.1% sensitivity, outperforming six routine ...
Lung cavities in tuberculosis linked to microbial imbalance, study finds
A retrospective study of 189 tuberculosis patients found that cavitary pulmonary tuberculosis is associated with higher abundance of Mycobacterium tuberculosis ...
Sequencing Test Shows High Accuracy for Detecting Mycoplasma Pneumonia in Children
A meta-analysis of seven studies reports pooled sensitivity of 0.94 and specificity of 0.98 for mNGS in diagnosing pediatric Mycoplasma ...
Sequencing donor and recipient samples reveals hidden pathogen transmission in liver transplants
Metagenomic sequencing of matched liver transplant donor–recipient pairs outperformed culture, uncovered possible donor-derived pathogen transmission, and informed antimicrobial therapy in ...
Klebsiella pneumoniae brain abscess linked to TIPS stent infection in first reported case
Physicians in Chengdu report the first documented case of a Klebsiella pneumoniae brain abscess arising from endotipsitis, an infection of ...
Targeted Sequencing Outperforms Smears in Spotting Hidden Lung Infection Pathogens
A large Chinese cohort study found that both metagenomic and targeted next-generation sequencing of lung fluid outperformed conventional tests for ...
Plasma microbial DNA sequencing catches hidden infections after liver transplantation
A prospective South Korean cohort study found that plasma microbial cell-free DNA metagenomic sequencing substantially agreed with conventional microbiology when ...
Metagenomic Sequencing Reveals Hidden Fungal Co-Infection in Fatal Infant Pertussis Case
A case report in BMC Pediatrics describes how metagenomic next-generation sequencing uncovered a fatal Pneumocystis jirovecii co-infection in a two-month-old ...
Sequencing Showdown: Two DNA Tests Match Up in the Race to Diagnose Tuberculosis
A propensity score-matched study of 403 patients finds targeted and metagenomic next-generation sequencing statistically equivalent for diagnosing pulmonary tuberculosis, though ...
Kitten Scratch Triggers Rare Deadly Immune Syndrome in Kidney Transplant Patient
Clinicians in Chongqing report an extremely rare case in which Bartonella henselae bacteremia from a kitten scratch triggered hemophagocytic lymphohistiocytosis ...
Rare Black Yeast Fungus Linked to Lung Inflammation in Landmark Case Report
A rare case report from China describes a man whose diffuse pulmonary nodules were ultimately attributed to the black yeast ...
Study Finds DNA Testing Identifies Lung Pathogens Three Times More Effectively Than Traditional Methods
In the rapidly evolving landscape of infectious disease diagnostics, a groundbreaking study has illuminated the immense potential of Metagenomic Next-Generation ...
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