GNAZ Slows Lung Cancer Growth by Triggering KIF11 Destruction and Boosts Osimertinib Response
New research in Cell & Bioscience shows that the G-protein subunit GNAZ suppresses lung adenocarcinoma by promoting HUWE1-mediated degradation of ...
Tag: lung adenocarcinoma
Cediranib plus KRASG12C inhibitors triggers replication stress and antitumor immunity
A new study reports that combining the multi-target kinase inhibitor cediranib with KRASG12C inhibitors overcomes resistance by sustaining ERK blockade, ...
IGF2BP3 stabilizes TROAP mRNA and suppresses ferroptosis in non-small cell lung cancer
A new study reports that the m6A reader protein IGF2BP3 promotes non-small cell lung cancer progression by stabilizing TROAP mRNA ...
S100P Emerges as a Prognostic and Immune-Linked Biomarker in Lung Adenocarcinoma
A bioinformatics and single-cell study finds that S100P is elevated in lung adenocarcinoma, tracks with advanced stage and poorer survival, ...
Stage, EGFR Status and CEA Predict Brain Metastasis Risk in Lung Cancer
A retrospective Chinese cohort study found that advanced T stage, nodal involvement, EGFR mutation, and elevated serum CEA were associated ...
TGF-β Suppresses Glycolytic Enzyme PFKM, Fueling Metabolic Shift and EMT in Lung Cancer
A new study shows that TGF-β-driven PFKM downregulation reroutes glucose toward glycogen storage and promotes invasive, mesenchymal-like behavior in lung ...
NLRC4 Acts as a Non‐Canonical Tumour Suppressor in Lung Adenocarcinoma by Inhibiting PI3K/AKT/mTOR Signalling to Induce Protective Autophagy
A new study shows that the immune sensor NLRC4 acts as a tumour suppressor in lung adenocarcinoma by restoring PTEN ...
Lung Cancer Rewrites Its Identity: Rare Squamous Transformation Tracked by Genomic Sequencing
A case report documents an EGFR-mutant lung adenocarcinoma transforming into squamous cell carcinoma after multiple therapies, with newly detected SMAD4 ...
Rare EGFR Mutation Shows Primary Resistance to Afatinib in Lung Cancer Case
A case report documents rapid progression and death in a lung cancer patient with a rare EGFR PACC mutation who ...
Swollen Limbs That Fooled Rheumatologists: Lymphedema Unmasked Hidden Cancers in Six Patients
A Chinese case series reports six patients whose unexplained lymphedema was the first sign of paraneoplastic rheumatic syndromes, with hidden ...
Case Report Documents 43-Month Survival After Small-Cell Transformation of EGFR-Mutant Lung Cancer
A Chinese case report documents 43-month survival after EGFR-mutant lung adenocarcinoma transformed into small cell lung cancer and was treated ...
Hidden Protein Shield Helps Lung Tumors Survive Osimertinib Treatment
A new study shows that ZNF593-driven SUMOylation stabilizes the stress-responsive protein ANKRD1, which activates MERTK-AKT survival signaling and promotes acquired ...
Rare EGFR variant linked to sharply elevated lung cancer risk
A study of 3.37 million people of European ancestry associated the rare inherited EGFR T790M variant with about 25 times ...
A tight inducible model for oncogene function and drug testing
A cell-based study showed that a tightly regulated expression platform reproduced variant-specific responses to cabozantinib in engineered human A549 lung ...
Collagen-Targeted MRI Agent Spots Tiny Lung Tumors and Hidden Metastases in Preclinical Tests
A collagen-targeted protein MRI contrast agent developed at Georgia State University detected invasive lung tumors and multi-organ metastases as small ...
Clinicopathological and molecular correlates of micropapillary/solid and lepidic patterns in lung adenocarcinoma
A retrospective study of 73 Chinese patients links micropapillary/solid and lepidic components in invasive non-mucinous lung adenocarcinoma with distinct clinical, ...
Whole-genome liquid biopsy predicts early lung cancer recurrence
A patient-specific whole-genome liquid biopsy detected lung cancer DNA associated with recurrence months before tumors became visible on imaging in ...
Retrospective study links postoperative recurrence to longer survival with osimertinib
A six-center retrospective study of 275 osimertinib-treated patients associated postoperative recurrence with longer progression-free and overall survival than de novo ...
Chilli extract shows preclinical activity against lung adenocarcinoma in rats
A chemically complex chilli-pepper extract reduced proliferation, inflammation and oxidative-stress markers in a DEN-induced rat model of lung adenocarcinoma, with ...
Review maps NSCLC-to-SCLC transformation amid expanding lung cancer treatments
A 2026 literature review synthesizes clinical, diagnostic, molecular and therapeutic evidence on transformation from non–small cell lung cancer to small ...
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