Tag: lung adenocarcinoma

A binational spatial immunophenotyping study of 581 non-small cell lung cancer patients demonstrates that macrophage proximity to cancer cells and ...

Tissue CXCL12 Associates with T-bet and Longer Lung Adenocarcinoma Survival

In an institutional lung adenocarcinoma cohort, higher tissue CXCL12 expression was associated with increased T-bet abundance and longer overall survival.

Triple Therapy Fails to Prevent Lung Cancer Transformation but Clarifies Resistance

A clinical trial evaluating a triple combination therapy in EGFR-mutant lung cancer found that TP53 and RB1 mutations drive treatment ...

Targeted Lung Adenocarcinoma Sequencing Reaches Prognostic Gene Discovery Plateau at 700 Samples

In targeted sequencing of non–small cell lung cancer, prognostic gene discovery increases linearly with cohort size before reaching a plateau ...

Gallium-68 Radiolabeled EMP-100 PET Effectively Maps c-Met in Preclinical Lung Cancer

A preclinical evaluation reveals that PET/CT imaging with gallium-68 labeled EMP-100 non-invasively quantifies cell-surface c-Met receptor expression across diverse non-small ...

Deep Learning Outperforms Classical Algorithms in Benchmark for Cancer Histopathology Segmentation

A narrative review and multi-dataset benchmark shows deep learning algorithms outperform classical thresholding methods in segmenting cell nuclei across major ...

Rare Skin Marker Linked to Early-Stage Lung Cancer in Case Report

A clinical case report and literature review found that the eruptive skin condition known as the Leser–Trélat sign can develop ...

Mild JPEG2000 Compression Cuts Pathology Storage By Ninety Percent While Preserving Accuracy

Evaluating lung adenocarcinoma whole-slide images revealed that mild JPEG2000 compression reduces storage requirements by approximately 90% while maintaining deep learning ...

RFX2 Loss Promotes Immune Escape in Lung Adenocarcinoma via Hippo Signaling

Downregulation of the transcription factor RFX2 promotes immune escape and tumor progression in lung adenocarcinoma by suppressing RASSF1 and reducing ...

STING Activation Remodels Suppressor Cells to Inhibit Lung Adenocarcinoma Growth

Pharmacological activation of STING signaling remodels myeloid-derived suppressor cells and suppresses tumor progression in lung adenocarcinoma models.

GATA1 Activates HSD17B6 to Enhance Cisplatin Sensitivity in Lung Adenocarcinoma Cells

Researchers discover that transcription factor GATA1 transactivates HSD17B6 to overcome cisplatin chemoresistance in lung adenocarcinoma cells by promoting DNA damage.

METTL16 Drives Lung Cancer Progression via GTSE1 Modification

A new study reveals that METTL16 accelerates lung adenocarcinoma progression by modifying GTSE1 via m6A, thereby regulating the p53 pathway ...

AI Virtual Imaging Improves Lung Cancer Grading

A new deep learning framework uses virtual imaging to improve the objective grading and prognostic stratification of lung adenocarcinoma from ...

Y Chromosome Loss Linked to Immunotherapy Benefit in Male Lung Cancer

A retrospective analysis of three randomized trials suggests that Y chromosome loss is associated with improved survival in male lung ...

Study Identifies Metabolic Vulnerabilities and Resistance Pathways in Murine Lung Adenocarcinoma

Researchers conducted an in vivo CRISPR screen to identify metabolic dependencies and pathways tied to anti-PD1 resistance in oncogenic Kras-driven ...

Oxeiptosis Gene Signature Predicts Lung Adenocarcinoma Prognosis and Highlights PSMD2 Role

Researchers developed a seven-gene prognostic model linked to oxeiptosis in lung adenocarcinoma and demonstrated experimentally that silencing PSMD2 impairs tumor ...

Photon Counting CT Spectral Parameters Show Noninvasive EGFR Prediction in Lung Adenocarcinoma

A retrospective study of seventy-two lung adenocarcinoma patients indicates that quantitative spectral parameters from photon-counting computed tomography can noninvasively assist ...

Lab-based XGBoost model predicts lung adenocarcinoma recurrence on EGFR-TKIs