LKB1 Axis Regulates Aerobic Glycolysis and Tamoxifen Resistance in Breast Cancer Models
Researchers found that miR-8072 and LKB1 regulate aerobic glycolysis and tamoxifen sensitivity in estrogen receptor-positive breast cancer models and patient ...
Tag: LKB1
New mouse model of metastatic prostate cancer opens door to combination immunotherapy studies
Researchers developed PL051, a syngeneic mouse prostate cancer cell line that is androgen-dependent, metastatic and immunocompetent, enabling tests of combined ...
Patient-Derived Heart Cells Reveal Susceptibility to Osimertinib-Induced Cardiac Dysfunction
Heart muscle cells grown from lung cancer patients reproduce individual susceptibility to osimertinib-induced cardiac dysfunction, with impaired AMPK–LKB1 signaling marking ...
LKB1 Loss Reveals Leptin’s Role in Cancer Therapy
In the ever-evolving landscape of cancer research, a groundbreaking study has emerged that elucidates a novel mechanism linking the loss ...
