Tag: lipid nanoparticles

A new review surveys the analytical techniques used to characterize mRNA drug substance quality attributes and assesses which could be ...

In a head-to-head mouse study, an adenoviral RSV vaccine built stronger systemic immunity while a self-amplifying RNA vaccine preferentially established ...

A new review finds that mRNA vaccines and host-directed therapeutics for multidrug-resistant ESKAPE bacteria remain preclinical, with no licensed bacterial ...

A new review maps the molecular, computational and experimental landscape of off-target CRISPR editing as gene therapies advance toward the ...

A new review argues that lipid nanoparticles, already clinically validated as mRNA carriers, could unify cancer therapy around restoring the ...

A structured narrative review proposes an eight-step decision framework linking liposome design variables to pulmonary barriers, aerosol platforms, and quality ...

Binghamton University researchers received SUNY seed funding to develop an AI pathology model and an amino-acid-based nanoparticle platform for delivering ...

A PLoS Biology perspective argues that the real challenge in treating neurodegenerative disease is no longer crossing the blood–brain barrier, ...

A Journal of Translational Medicine review outlines how mRNA-encoded antibodies, bispecific constructs, and transient CAR expression could overcome the manufacturing ...

A collaborative laboratory study found that storage-buffer choice can change the structure, stability and cell-delivery performance of mRNA lipid nanoparticles ...

An AI-guided lipid nanoparticle formulation remained functional after two months at 37 degrees Celsius or one year at room temperature ...

A new cross-platform review of eighteen FDA-approved RNA therapeutics finds that adverse effects depend more on delivery chemistry and administration ...

A new review charts how in vivo CAR-T engineering could transform customized living drugs into scalable, off-the-shelf genetic medicines.

Infant neuroblastoma is one of the most clinically paradoxical cancers in medicine. Diagnosed during the first year of life, it ...

Australian researchers have completed the first head-to-head comparison of three mRNA-lipid nanoparticle vaccine platforms in human blood, revealing key differences ...

Researchers redesigned lipid nanoparticles to cut liver accumulation of locally injected mRNA by up to eighty-fold in mice while preserving ...

A new review details how micro- and nanoencapsulation technologies are overcoming the poor stability, solubility, and bioavailability of plant-derived bioactive ...

New research in mice and pigs shows that the placental hormone GDF15 drives fetal growth by activating a STAT3-IGF2 signaling ...

MIT engineers have developed lipid nanoparticles that reprogram natural killer cells inside the body to destroy cancerous and autoreactive T ...

MIT researchers have engineered ligand-directed lipid nanoparticles that reprogram natural killer cells into CAR-bearing cancer killers directly inside living animals, ...