Tag: immunotherapy

A new study shows that the protein SIRPα, produced by esophageal cancer cells themselves, fuels both tumor growth and T-cell ...

Spanish researchers have developed a humanized monoclonal antibody, hB101.37, that inhibits the BAMBI pseudoreceptor and rebalances T cell immunity, showing ...

A new systematic review and meta-analysis finds that myasthenia gravis beginning at age 65 or older carries more than double ...

A matching-adjusted indirect comparison of two landmark trials suggests retifanlimab significantly prolongs progression-free survival compared with avelumab in metastatic Merkel ...

A new Nature Reviews Clinical Oncology review synthesizes epidemiological, trial and mechanistic evidence to argue that structured exercise is emerging ...

Penn State researchers found that blocking the protein VPS34 raises levels of the GD2 molecule on neuroblastoma cells, making them ...

A new scoping review of 30 studies synthesizes the emerging evidence on time toxicity in cancer care, showing how treatment ...

A two-year real-world study found that ofatumumab sustained B-cell depletion in multiple sclerosis patients while producing significant increases in broad ...

Researchers have engineered a custom ionizable lipid nanoparticle that delivers CAR-encoding mRNA into human T cells with over 90 percent ...

A metal–organic framework nanovaccine co-delivering tumour antigens and STING agonists induced systemic tumour regression, immune memory and synergy with radiotherapy ...

Hematologists argue that preventive dental care and oral health assessment should become a standard part of the CAR-T cell therapy ...

A new review in Cancer Cell International details how cancer-associated fibroblasts remodel the colorectal tumor microenvironment and drive resistance to ...

A new Nature Cancer study reveals that the kinase GSK3β in colorectal tumor cells drives fumarate accumulation that epigenetically reprograms ...

New preclinical research shows that the plant compound coumarin activates natural killer cells, boosts their mitochondrial energy supply, and shrinks ...

A real-world study of 95 patients in Tokyo confirms that pembrolizumab combined with chemotherapy before and after surgery delivers event-free ...

A new review proposes co-designing oncolytic viruses and CAR-T or CAR-NK cells as a modular, self-amplifying therapeutic system to overcome ...

A new review maps how cancer-associated fibroblasts exclude immune cells from osteosarcoma tumors and outlines the therapeutic strategies that could ...

A new commentary synthesizes how gut microbial dysbiosis drives colorectal, gastric, and liver cancer and how microbiome-based diagnostics and therapies ...

Single-cell analysis of 56 glioblastoma tumors reveals that T-cell-rich cases harbor clonally expanded, LAG3-high CD8 T cells that may be ...

Researchers have developed engineered feeder cells derived from induced pluripotent stem cells that prolong the survival and boost the killing ...