A new review argues that tumor acidity, hypoxia, reactive oxygen species and microbial cues can fundamentally alter the degradation, activation ...
Human umbilical cord mesenchymal stem cell exosomes reduced kidney fibrosis in a preclinical model by delivering pVHL, which drives HIF-1α ...
A new hypothesis-driven review proposes that compound deep-underground exposures could modify pulmonary embolism susceptibility and recognition, while stressing that direct ...
A new review maps how metabolite-driven protein modifications such as lactylation, O-GlcNAcylation and succinylation may link the disc's harsh metabolic ...
A prospective cohort of 169 sepsis patients at a Mogadishu tertiary emergency department found an in-hospital mortality rate of 30.2 ...
A pan-cancer analysis of 16 tumor types finds that elevated DNA methylation variability is consistently associated with genomic instability, aggressive ...
A new study shows that hydrogen peroxide treatment triggers distinct gene expression responses in the wood-decay fungus Phlebia radiata depending ...
A microfluidically fabricated liposome co-loaded with a copper phthalocyanine photosensitizer and catalase cut hypoxic C6 glioma cell viability to about ...
A new study links the metabolic enzyme ECHS1 to hypoxia-responsive PGK1 crotonylation and malignant phenotypes in prostate cancer cell and ...
A comparative metabolomic study of five bivalve species finds that longer lifespans align with a reorganization of TCA cycle intermediates ...
A Frontiers Research Topic editorial brings together studies on how the human body manages energy supply under cold, high-altitude, desert ...
A cross-sectional study of 198 high altitude polycythemia patients identified four immune phenotypes and found a low monocyte-to-lymphocyte ratio strongly ...
A new review argues that dysfunctional blood vessels, through failed endothelial quiescence, abnormal remodeling modes and disrupted angiocrine signaling, may ...
A cell and patient-cohort study links hypoxia-induced GP73 to HIF-1α-dependent glycolysis, growth, invasion and markers of transarterial chemoembolization resistance in ...
A retrospective study of 46 adults with Alström syndrome found no diffuse pulmonary fibrosis on HRCT scans or post-mortem tissue, ...
A laboratory study finds that the approved kinase inhibitor lapatinib can improve retention of a nanoparticle sonosensitizer in hypoxic prostate ...
A multi-method study linked chronic high-altitude exposure to elevated α-synuclein levels and worse pathology in a mouse model, while human ...
A review identifies inflammation and immune readjustment as central factors in chemotherapy-related fatigue among breast cancer patients, while noting that ...
A machine-learning and cell-culture study found that shikonin induced necroptosis and apoptosis in hypoxic MDA-MB-231 breast cancer cells through a ...
A case-study report of six trahira from Brazilian temporary pools found lip protuberances in three fish from a low-oxygen drying ...
