Low Oxygen Turns Inflammatory Switch That Drives Oral Cancer Growth
New research in the British Journal of Cancer shows that oxygen-starved oral cancer cells activate an HMGB1-driven NLRP3 inflammasome pathway ...
Tag: hypoxia
Cellular Stress Hubs Help Oral Cancer Spread, Study Finds
New research shows that stress-induced eIF2α phosphorylation drives stress granule formation that promotes growth and metastasis in oral squamous cell ...
One MicroRNA, Two Missions: Duplex From Pre-miR-16 Strikes Both VEGF and Hypoxia Pathways in Lung Cancer
A new Cell Death Discovery study shows that the two strands of the pre-miR-16-1 microRNA duplex can cooperatively suppress both ...
How Tumors Survive Radiation: Plastic Cells and Tolerant Niches Drive Recurrence
A new review in Molecular Cancer reframes radioresistance as an ecosystem-level phenomenon in which plastic residual tumor cells survive radiation ...
Low Oxygen Inside Tumors Fuels Cervical Cancer Growth and Cisplatin Resistance, Study Finds
Researchers at Chongqing Medical University report that hypoxia silences the tumor suppressor CCNDBP1 in cervical cancer, activating a USP11–Nrf2 antioxidant ...
Microbes, not just warmth, may drain oxygen from a warming Celtic Sea
A new oxygen budget for the Celtic Sea shows that microbial respiration, amplified by warming, could push deep shelf waters ...
Two-Pronged Immunotherapy Strategy Cracks Glioblastoma’s Defenses in Preclinical Study
Wistar Institute scientists report that combining the kidney cancer drug axitinib with a 4-1BB agonist overcame myeloid cell suppression and ...
Seizure-Like Episode During Pacemaker Surgery Points to Rare Air Embolism Danger
A case report describes a pacemaker patient who developed seizure-like activity and acute hypoxia from suspected venous air embolism, highlighting ...
Cellular Bridges Under Low Oxygen: How ER-Mitochondria Contacts Drive Gastric Injury
A new study reveals how hypoxia-driven ER-mitochondria contact sites and the membrane-rupturing protein NINJ1 conspire to destroy the gastric lining ...
Plant Cell Walls Hold Firm Under Everest-Level Low Pressure, Study Finds
New research shows that Arabidopsis cell wall matrix polysaccharides remain biochemically unchanged under hypobaric pressures as low as 33 kilopascals, ...
Blood’s Hidden Trick: Plasma Volume, Not Just Red Cells, Drives Altitude Hemoglobin Rise
A study of 281 Andean residents shows that plasma volume contraction begins at lower altitudes than red cell production and ...
Plateau Fish Rewire Their Immune Systems to Survive Oxygen Starvation
A new genomic study reveals that the Tibetan plateau fish Gymnocypris eckloni deploys distinct immune strategies against severe short-term and ...
Does Living Higher Protect Against COVID-19 Deaths? A New Meta-Analysis Weighs the Evidence
A systematic review and meta-analysis of 17 studies finds hints that high altitude may protect against COVID-19 death, but very ...
Iron’s Master Switch: How Cells and the Body Keep the Perfect Balance
A new review maps the molecular circuits, from intracellular IRE-IRP sensors to the liver hormone hepcidin, that keep the body's ...
PRMT6 Boosts Temozolomide Resistance in Glioblastoma
Recent advances in cancer research have uncovered a startling mechanism behind the resistance of glioblastoma multiforme (GBM) to the chemotherapeutic ...
Hypoxia’s Role in m6A Regulation in Liver Cancer
In the intricate realm of cancer biology, the role of epitranscriptomics—specifically the m^6A methylation of RNA—has emerged as a significant ...
