Tag: hypertrophic cardiomyopathy

A retrospective study of children with cardiomyopathy carrying TNNI3 variants reveals marked phenotypic heterogeneity and severe clinical outcomes in restrictive ...

In a murine model of hypertrophic cardiomyopathy, four weeks of activin receptor inhibition with CDD866 increased skeletal muscle mass, attenuated ...

A deep learning pipeline combining cine magnetic resonance imaging and scar size accurately differentiated hypertrophic cardiomyopathy from hypertensive heart disease ...

In a case report published in the journal BMC Cardiovascular Disorders, researchers detailed a rare and complex presentation of cardiac ...

An integrative transcriptomic study reveals that interferon-associated macrophage states accompany cardiac fibroblast activation in hypertrophic cardiomyopathy without an increase in ...

Researchers validated a noninvasive corrected myocardial work method to assess left ventricular function and mechanical remodeling in hypertrophic obstructive cardiomyopathy.

A long-term analysis of the phase 3 EXPLORER-CN trial shows that mavacamten provided sustained improvements in patient-reported health status over ...

A bioinformatics and laboratory study identified FKBP5, MYH6 and PROS1 as candidate endoplasmic reticulum stress-related feature genes in hypertrophic cardiomyopathy.

A standardized Drosophila imaging platform identified heart segment A3 as the optimal measurement site and enabled fly models of dilated ...

A narrative review of seven studies finds that measuring heart obstruction after a meal detects left ventricular outflow tract blockage ...

A new review in Cardiovascular Ultrasound synthesizes how advanced imaging, genetic testing and cardiac myosin inhibitors are transforming the diagnosis ...

A qualitative study of 21 adults with familial cardiomyopathy finds that perceived disease severity, family history and safety uncertainties shape ...

A prospective study of 20 patients found that squats, the Valsalva maneuver, and bicycle exercise stress echocardiography provoked similar maximal ...

A retrospective Canadian study of 115 patients found mavacamten improved symptoms and reduced outflow tract obstruction in routine care, with ...

Whole-exome sequencing of 568 cardiomyopathy patients found pathogenic variants in nearly three-quarters of those with restrictive filling physiology, with MYBPC3, ...

A multi-omics analysis of human hypertrophic cardiomyopathy found suppressed glycolytic transcription but divergent enzyme-protein changes, while oxidative pathways declined more ...

The NIH-funded BabyMERIT trial will test trametinib in 25 infants with severe hypertrophic cardiomyopathy associated with Noonan syndrome and related ...

A new critical review finds that AI-enabled ECG has reached clinical maturity in STEMI triage and reduced ejection fraction screening ...

A new bibliometric analysis of 367 articles maps two decades of cardiac diffusion MRI research, identifying diffusion tensor imaging as ...

A three-parameter cardiac MRI model combining myocardial strain and tissue characteristics can identify hypertrophic cardiomyopathy patients whose outflow tract obstruction ...