Tag: host-directed therapy

Researchers have identified the human enzymes PTGR1 and PTGR2 as the cause of an unprecedented metabolic inactivation of the antitubercular ...

New laboratory research shows that macrophages from people with cystic fibrosis are intrinsically impaired in controlling the virulent rough morphotype ...

The ATR inhibitor AZD6738 reversed about 57% of the LPS-induced inflammatory gene program in mouse corneas and suppressed an NF-κB-centered ...

A new review argues that virtual screening and AI-driven modeling have expanded the search for anti-tuberculosis drugs, but persistent mismatches ...

Experimental laboratory and mouse studies found that PGK1’s non-canonical kinase activity promotes degradation of a host chaperone needed by several ...

Korea University researchers used benchmarked AI models to design small-molecule fragments that experimentally inhibited the human enzyme DHPS, a host ...

A new Frontiers in Pharmacology perspective argues that dysregulated glucocorticoid receptor signaling is a shared upstream driver of chronic inflammation ...

A comprehensive review maps how approved drugs—from anticancer agents to antidepressants—can be systematically repurposed to combat drug-resistant superbugs.

A systematic review of 252 studies published between 2024 and 2026 shows natural products dominating antimalarial discovery while warning that ...

A new PLOS Pathogens study finds that the microRNA-1246 regulates macrophage lipid metabolism and helps explain why some household contacts ...

A new review maps how plant-derived flavonoids attack tuberculosis through multiple molecular mechanisms while outlining the structural features and delivery ...

Researchers report that the steroid sulfatase inhibitor irosustat and its target molecule cholesterol sulfate inhibit drug-resistant Plasmodium falciparum through a ...

An innovative approach to combating tuberculosis (TB), one of the world’s deadliest infectious diseases, has emerged from groundbreaking research at ...