Sex May Modify Obesity-Related Heart Failure Physiology but Not Treatment Eligibility
A targeted review in Biology of Sex Differences finds that sex may modify selected adiposity and exercise hemodynamics in obesity-related ...
Tag: HFpEF
Echocardiographic markers distinguish combined from isolated postcapillary pulmonary hypertension in systemic sclerosis
A single-center study of 147 adults with systemic sclerosis and heart failure with preserved ejection fraction identified echocardiographic strain and ...
CaMKII Emerges as Central Molecular Hub Driving the Ageing Heart
A new review synthesizes preclinical evidence that the CaMKIIδ kinase integrates calcium dysregulation, inflammation, autophagy failure, mitochondrial decline and DNA ...
GLP-1 drugs may not help every form of heart failure, researchers warn
A new commentary argues that GLP-1 receptor agonists' heart failure hospitalization benefit may not apply across all heart failure phenotypes.
Clinical obesity flags higher risk in heart failure with preserved ejection fraction
A prospective cohort of 426 Chinese HFpEF patients found clinical obesity in 74.9 percent and roughly double the risk of ...
GLP-1 drugs emerge as multi-organ protectors far beyond blood sugar control
A new narrative review argues that GLP-1 receptor agonists should be repositioned as foundational cardio-renal-metabolic protectors, with trial evidence extending ...
Microvascular Disease May Link Diabetes to Heart Failure With Preserved Ejection Fraction
A new review argues that heart failure with preserved ejection fraction in diabetes may represent a cardiac manifestation of diabetic ...
Retrospective single-center study finds 33.4% mortality in hospitalized heart failure
A retrospective single-center study of 1,000 heart-failure patients hospitalized in northern Iran found 33.4% all-cause mortality, with older age and ...
Higher Platelet-to-White Blood Cell Ratio Linked to Survival in HFpEF
In a retrospective study of critically ill adults with HFpEF, a higher early platelet-to-white blood cell ratio was independently associated ...
Finerenone Shows Favorable Real-World Profile in Chinese Heart Failure Patients
A 12-month real-world observational study of 73 Chinese heart failure patients at Tongji Hospital found finerenone was associated with favorable ...
Routine Heart MRI Reveals Hidden Damage in a Common, Elusive Form of Heart Failure
A retrospective single-center analysis of 126 adults shows that routine cine cardiovascular magnetic resonance can identify left atrial enlargement, ventricular ...
Hypertensive Stress Rewires Immune Cell Signals in a Common Heart Failure Syndrome Independent of Obesity
A new study shows that hypertensive stress rewires cardiac macrophage signaling, impairing metabolic support for heart muscle cells while driving ...
Sotatercept May Reach Beyond Pulmonary Hypertension Into Heart Failure and Transplant Care
An opinion article argues that the activin-trap drug sotatercept, proven in pulmonary arterial hypertension and supported by the CADENCE trial ...
How Stressed Blood Flow and Metabolism Drive Ageing Arteries
A new review proposes that disturbed blood flow and metabolic stress converge to drive endothelial cell senescence, amplifying cardiometabolic vascular ...
CTRP9 Enhances Heart Failure by Modulating Lipid Metabolism
Recent research published in the Journal of Translational Medicine has brought to light the promising potential of CTRP9 in addressing ...
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