Dual Cell Line Genome Editing Clarifies Cancer Risks of Rare BRCA1 Variants
Saturation genome editing across human haploid and mammary epithelial cells resolves mechanisms of variant pathogenicity and refines breast cancer risk ...
Tag: HAP1 cells
Testing BRCA1 Variants Across Cell Types Clarifies Breast Cancer Risk Differences
Researchers using saturation genome editing across cell types found that mammary cells can buffer some BRCA1 mutations, helping distinguish high-risk ...
SETDB1 and HUSH Complexes Restrict Single-Stranded DNA Incorporation During Genome Editing
Researchers have identified the SETDB1/ATF7IP heterodimer and HUSH complex as major epigenetic barriers that restrict single-stranded DNA incorporation during nickase-mediated ...
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