Moving Affinity Tags Inside Proteins Fixes Purification Issues
Internalizing affinity tags within secreted Chlamydomonas proteins enables efficient purification via Ni-NTA chromatography, overcoming previous proteolytic truncation issues.
Tag: Glycosylation
Two C3 Gene Variants Reveal Functional Independence Between Extracellular and Intracellular Forms of Complement C3
Two C3 variants remained detectable inside cells despite severe plasma depletion, showing extracellular and intracellular complement C3 represent functionally independent ...
Mouse Saliva Evolves Fast, Driven by Gene Duplication and Sex-Biased Regulation
A comparative genomic study finds that most secreted-protein expression in mouse salivary glands comes from lineage-specific genes, with sex-biased expression ...
Biosimilar SB16 Matches Denosumab in Exhaustive Analytical Comparison
A comprehensive analytical characterization shows the newly approved denosumab biosimilar SB16 is highly similar to Prolia and Xgeva across structure, ...
Pediatric glioma proteogenomics identifies age-linked targets, not therapies
An observational proteogenomic study of 112 pediatric and young-adult high-grade glioma tumors found age- and sex-associated molecular differences and four ...
NIH-funded study probes PFAS and pre-diagnostic changes in IBD
A five-year NIH-funded Mount Sinai study will examine associations between PFAS exposure, pre-diagnostic glycosylation changes and later inflammatory bowel disease ...
Review links protein modifications to ulcerative colitis mechanisms
A review finds that protein modifications regulate immune inflammation and epithelial barrier dysfunction in ulcerative colitis through mechanisms that remain ...
NIH grant funds research linking metabolism and glycosylation in rare diseases
A five-year NIH award will support Greenwood Genetic Center research using zebrafish models to examine how metabolism and glycosylation jointly ...
Sugar Coats on Death Receptors Act as Molecular Switches Deciding Cell Fate
A new review reveals that sugar chains attached to death receptors act as molecular checkpoints that determine whether cells undergo ...
From Glycans to Mitochondria: Women Scientists Map the Frontiers of Cell Death Research
A new Frontiers in Cell Death Research Topic curated by women scientists collects five studies spanning necroptosis, death receptor glycans, ...
Simple Sugar Fucose Shows Promise as New Treatment for GLUT1 Deficiency Syndrome
A case report in the Journal of Neurology documents systemic and central nervous system hypofucosylation in a child with GLUT1 ...
Inside the Cell’s Metal Highway: How Zinc, Manganese, and Iron Reach the ER and Golgi
A new review maps how zinc, manganese, and iron are transported into the ER and Golgi apparatus, revealing transporter families ...
Sand Fly Saliva Test Shows Protein Factory Choice Can Make or Break Exposure Assays
A new study shows that the cellular expression system used to produce the sand fly salivary protein SP32, particularly insect-derived ...
The Golgi Apparatus Emerges as a Hidden Driver of Alzheimer’s Disease
A new review argues that the long-overlooked Golgi apparatus, supported by human genetic, proteomic, and lipidomic evidence, may be a ...
Sugar Switch on Immune Cells Could Push Macrophages Back Into Cancer-Fighting Mode
Researchers found that blocking the enzyme ST6GAL1 reverses a sugar-linkage switch on macrophages, restoring tumor-fighting behavior and slowing colorectal cancer ...
Scientists unlock rice protein’s hidden power as a plant-based emulsifier
A new review in Food Chemistry: X details how physical, chemical, and enzymatic modifications can transform rice protein's rigid structure ...
CA 15-3 and CEA Tumor Markers Used in the Diagnosis and Monitoring of Cancer
CA 15-3 is an epitope of the MUC1 glycoprotein. MUC1 is a transmembrane mucosa-associated glycoprotein and contains a large extracellular ...
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