Fumarate Impairs DNA Repair in Kidney Cancer Cells
A new study reveals that fumarate accumulation in kidney cancer cells impairs DNA repair by modifying the RPA1 protein, leading ...
Tag: genomic instability
Maternal Deprivation Model Links Hippocampal Senescence to ASD Pathways
A study in Cellular and Molecular Neurobiology identifies hippocampal senescence-like alterations in a maternal deprivation rat model, linking them to ...
Targeted Deep Sequencing Tracks Y Chromosome Loss and Blood Clones Together
A targeted deep sequencing method simultaneously estimates mosaic Y chromosome loss and CHIP-related mutations, validated in over 400 male patients ...
Mushrooms and the Molecules of Longevity: What the Evidence Really Shows
A new review argues that mushrooms and the antioxidant L-ergothioneine show anti-aging effects in laboratory models, while human evidence remains ...
Splicing protein LSM5 linked to aggressive growth in osteosarcoma cells
An integrative analysis finds the splicing protein LSM5 over-expressed across cancers and linked to cell-cycle progression, migration and shorter survival ...
Tumors Show Heightened DNA Methylation Variability Tied to Instability and Worse Survival
A pan-cancer analysis of 16 tumor types finds that elevated DNA methylation variability is consistently associated with genomic instability, aggressive ...
Radioactive iodine therapy leaves measurable DNA damage in thyroid cancer patients
A Johannesburg study tracked micronuclei in thyroid cancer patients for six months after radioactive iodine therapy and found chromosomal damage ...
Radiation Damage Travels: How Bystander Cells Rewrite the DNA Story
A sweeping narrative review argues that radiation's non-targeted effects, from bystander signaling to biophoton emission and exosome release, are protective ...
Trapping rogue DNA rings in micronuclei could disarm aggressive tumors
An international research team has shown that rings of extrachromosomal DNA lose their cancer-driving activity when trapped in micronuclei, a ...
Tousled-Like Kinases TLK1 and TLK2 Emerge as Pan-Cancer Drivers of Genomic Instability and Immune Evasion
A pan-cancer analysis of 33 tumor types reveals that the DNA-repair kinases TLK1 and TLK2 drive genomic instability and shape ...
Jumping genes may explain why big dogs age faster and die younger
A large-scale study of 864 dogs finds that giant breeds lose methylation control over LINE1 jumping genes far faster than ...
Genome’s Silent Guardian: HUSH Complex Emerges as Key Player in Cancer
A systematic review in Medical Oncology details how the HUSH complex silences retrotransposons through H3K9me3 deposition and how its dysregulation ...
Genome Instability: Interplay with Immune Response
In recent years, the intersection of genomic instability and immune response has emerged as a compelling area of study, shedding ...
Transcription-Coupled Repair: Guardians of DNA Integrity
Transcription is a vital cellular process orchestrated by RNA polymerase II (Pol II), enabling the expression of genes that drive ...
