Tag: Fibrosis

A new narrative review in BMC Rheumatology summarises current best practice for managing systemic sclerosis, highlighting cellular therapies, multi-omics and ...

A rat study found that biological sex modified both radiation-induced lung injury patterns and the effectiveness of enalapril, metformin and ...

A bone marrow chimera study in mice shows that deleting the CLEC4E receptor in cardiac resident cells, rather than in ...

A new review describes standardized MRI criteria for assessing healing and healed status in perianal fistulising Crohn's disease, along with ...

A new review proposes an 'acute storm versus chronic siege' framework distinguishing how acute and chronic liver disease injure the ...

A new review finds that the receptor LOX-1 is linked to fibrotic remodeling across multiple organs, but its value as ...

A new review argues that dysfunctional blood vessels, through failed endothelial quiescence, abnormal remodeling modes and disrupted angiocrine signaling, may ...

A new review argues that calcific aortic valve disease is two diseases in one, and that imaging of both fibrous ...

In a laboratory study of primary pediatric lens epithelial cells, the anti-CTGF antibody pamrevlumab suppressed collagen production, migration and proliferation ...

A single-nucleus atlas of human visceral fat identifies THBS1-expressing stem cells and adipocytes as drivers of fibro-inflammatory remodeling in obesity ...

A Bayesian decision model suggests MASLD follow-up intensity should be calibrated to patient adherence, with aggressive monitoring favored for lifestyle-modification ...

A new review maps how the histone lactylation mark H3K18la links lactate metabolism to gene control, driving both disease progression ...

A paired tissue study of 11 patients finds that microRNA patterns tied to apoptosis and fibrosis remain largely unchanged after ...

In a rat model of paraquat-induced kidney damage, the approved drug disulfiram reduced tissue injury, fibrosis, and oxidative stress, with ...

A spatial transcriptomics study of 16 MASH patients and eight controls maps compartment-specific CYP450 suppression, immune activation, and disrupted cell-cell ...

A nationwide Danish register study of 331 chronic extracellular matrix-related conditions finds that 38% of the population lives with one ...

A small proof-of-concept study found that adolescents with repaired tetralogy of Fallot and moderate-severe right ventricular dilation on cardiac MRI ...

Researchers mapped a dense network of pain-sensing nerves in the kidney and showed in female mice that their neuropeptide CGRP ...

A multi-method study prioritized miR-539-3p and SOX9 as linked candidates in keloid tissue and fibroblasts, while leaving their regulatory relationship ...

A narrative review finds that copper can promote collagen cross-linking, oxidative stress, and cancer-cell activity in oral disease, but direct ...