Extrachromosomal DNA Emerges as Possible Breast Cancer Liquid Biopsy Marker
A new review finds plasma extrachromosomal DNA may complement cell-free and circulating tumor DNA measures in breast cancer liquid biopsy, ...
Tag: extrachromosomal DNA
Cancer’s rogue DNA: how ecDNA reshapes itself to survive treatment
A new review in Cellular Oncology argues that treatment resistance in cancer often stems from selection and remodeling of pre-existing ...
Long-read sequencing reveals the hidden genome of ovarian cancer
A new mini-review argues that long-read sequencing is exposing repetitive DNA, extrachromosomal DNA and complex structural variation that conventional methods ...
Trapping rogue DNA rings in micronuclei could disarm aggressive tumors
An international research team has shown that rings of extrachromosomal DNA lose their cancer-driving activity when trapped in micronuclei, a ...
Cancer’s Rogue DNA Can Backfire, Trapping Oncogenes in Micronuclei and Slowing Tumors
New research shows that damaged extrachromosomal DNA is trapped in transcriptionally silent micronuclei, impairing cancer cell fitness and predicting better ...
Chromatin maps reveal two hidden states driving colorectal cancer
A new review synthesizes single-cell chromatin accessibility studies showing that colorectal cancer is organized into two epigenomic states whose regulatory ...
Unveiling the Hidden DNA Circles Driving the Aggressiveness of Pancreatic Cancer
Researchers at the University of Verona, in collaboration with the University of Glasgow and the Botton-Champalimaud Pancreatic Cancer Centre, are ...
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