WTAP Regulates TRAF6 in Experimental HCC Models
A study in Frontiers in Cell and Developmental Biology identifies WTAP as a regulator of TRAF6 expression and vascular plasticity ...
Tag: Epitranscriptomics
Cell-Type-Specific Transcriptional and Epigenetic Regulation in Substance Use Disorder
A new Frontiers collection of seven studies shows that addiction's molecular changes are cell-type-specific, spanning epigenetics, RNA modification, and human ...
RNA’s Hidden M7G Code Shapes Cancer Growth, Immune Evasion, and Treatment Resistance
A new review maps how the m7G RNA modification acts across distinct RNA compartments to drive codon-biased translation, tumor adaptation, ...
Direct RNA Sequencing Reveals Epitranscriptomic Isoform Mechanisms in Heart Failure
Direct RNA sequencing of failing hearts reveals dynamic m6A remodeling and shows how transcript isoform switching drives apparent epitranscriptomic alterations ...
How Multilayered RNA Splicing Networks Drive Pancreatic Cancer Plasticity and Resistance
Researchers synthesize how coordinated epigenetic, transcriptional, and epitranscriptomic regulatory layers reshape alternative RNA splicing to drive pancreatic ductal adenocarcinoma progression ...
Multi-omics review maps molecular pathways tied to recurrent implantation failure
A systematic review of post-2017 multi-omics studies identifies three recurring molecular themes in recurrent implantation failure but concludes no single ...
RNA Modifications and Metabolism: Decoding Crosstalk in Liver Cancer
RNA modification networks and metabolic reprogramming establish reciprocal circuits that drive hepatocellular carcinoma progression and therapeutic resistance.
Single-cell atlas reveals inflammatory monocyte state tied to WTAP in healthy lungs and COPD
A single-cell atlas of healthy and COPD lung tissue identifies an HSPA1B-positive inflammatory monocyte state whose transcriptional program is associated ...
Bioinformatics analysis prioritizes 2,505 Arabidopsis genes linking m6A and alternative polyadenylation
A multi-dataset bioinformatics analysis prioritized 2,505 candidate Arabidopsis genes associated with links between m6A RNA modification and alternative polyadenylation under ...
RNA editing as an epitranscriptomic immune switch in tumor immunity and cancer immunotherapy
A review in Journal of Translational Medicine describes how dysregulated RNA editing suppresses tumor immune recognition and how programmable RNA ...
RNA Tag m6A Emerges as a Master Switch in Gene Control, Stress and Disease
A review in Nature Reviews Molecular Cell Biology explains how the RNA modification N6-methyladenosine regulates gene expression, enables cellular adaptation, ...
RNA 5-methylcytosine cancer biomarkers face a measurement gap, not a biology gap
A new review argues that the slow clinical translation of RNA 5-methylcytosine cancer biomarkers stems from a lack of analytically ...
RNA acetylation enzyme NAT10 drives aortic valve calcification through PCSK9
A new iScience study shows that the RNA acetyltransferase NAT10 stabilizes PCSK9 mRNA through N4-acetylcytidine modification, driving the osteogenic transformation ...
Ribosomal RNA Tag and a Detox Enzyme Form a Deadly Cancer Survival Circuit
A new review describes how the RNA methyltransferase METTL5 and the detox enzyme MGST1 form a signaling axis that helps ...
Two Molecular Machines, One Cancer Engine: How Deubiquitinases and m6A RNA Tags Talk to Each Other
A new review in Molecular Cancer maps the bidirectional crosstalk between deubiquitinases and m6A RNA modification, revealing a coupled regulatory ...
RNA edit swaps out OCT4 to make better stem cells
Researchers discovered that the RNA-modifying enzyme PUS7 pseudouridylates the noncoding RNA 7SK to recruit the BAF chromatin-remodeling complex, enabling a ...
RNA Cap Modification Emerges as a Switch That Governs Tumor Response to Radiotherapy
A new study shows that the RNA cap-modifying enzyme PCIF1 drives tumor growth and radioresistance, and that removing its m6Am ...
Leishmania Parasites Rewire Their Genes to Survive Antimony Drug Attacks
New research reveals that Leishmania parasites survive antimony treatment through active transcriptome remodeling, a transient persister state that may pave ...
Chemical Tag on RNA Helps Melanoma Dodge Ferroptosis, Study Finds
New research shows that the m6A reader protein YTHDF2 promotes melanoma progression by destabilizing HMOX1 mRNA and shielding tumor cells ...
Super Elongation Complex Found to Switch On Genes That Transform Cell Identity
New research shows that the Super Elongation Complex drives both stem cell reprogramming and neural differentiation by releasing paused RNA ...
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