Massive Turkish Genome Study Maps Hidden Mutation Patterns in Advanced Lung Cancer
A 1,500-patient next-generation sequencing study from Gazi University reveals EGFR and KRAS as dominant drivers in advanced NSCLC, with distinct ...
Tag: EGFR
Cancer’s Hidden Fingerprints: Tumor DNA Found in Body Fluids Beyond Blood
A new study shows that sequencing tumor DNA in ascites, pleural fluid, cerebrospinal fluid, and pericardial effusions can detect malignancies ...
Two-in-one boron compound fights tumors and powers neutron capture therapy
A carborane-quinazoline hybrid derived from erlotinib delivered boron to tumor cells far more efficiently than BPA and delayed tumor growth ...
Ginseng Compound Shows Promise Against Cancer and Superbugs in Virtual Screening
A computational study combining density functional theory and multi-target molecular docking finds that the Panax notoginseng compound notoginsenoside L1 binds ...
Digital Kidney Monitoring Passes the Clinical Test but Fails to Cut Costs, Danish Trial Finds
A Danish randomised trial found that patient-reported outcome based remote follow-up in chronic kidney disease was clinically non-inferior to usual ...
One in Three Older Diabetics Show Silent Bone Loss, Study Finds
A cross-sectional study of older Iranian patients with type 2 diabetes found that nearly one in three had osteoporosis, with ...
Antibody-Drug Conjugate Shows Striking First-Line Results in HER2-Driven Lung Cancer
A multicenter real-world study found that first-line trastuzumab deruxtecan doubled progression-free survival compared with chemotherapy in HER2-altered advanced NSCLC, while ...
Why EGFR Drugs Fail in Glioblastoma: A STAT3 Escape Route Takes Center Stage
A new review argues that glioblastoma evades EGFR-targeted therapies through compensatory STAT3 activation, positioning the EGFR–STAT3 axis as an adaptive ...
Spit Proteins Turn Up in Blood and Track Kidney Disease, Study Finds
A large human and mouse study shows that salivary proline-rich proteins circulate in serum and track chronic kidney disease with ...
Drug Repurposing Finds IGF1R Inhibitor That Reverses Radioresistance in Head and Neck Cancer
Researchers in Taiwan mapped a 25-microRNA regulatory network driving radioresistance in head and neck cancer and used transcriptome-guided drug repurposing ...
Gut Protein Claudin-2 Revealed as a Hidden Defender Against Dangerous E. coli Infections
New research in Nature Communications shows that the tight-junction protein claudin-2 protects mice from Citrobacter rodentium infection and colitis by ...
Two Cancer Genes Pull in Opposite Directions in Papillary Thyroid Tumors
A study of 125 papillary thyroid cancer patients finds that EGFR and GLI1 are both upregulated in tumors but inversely ...
Eye Damage in Diabetes May Signal Hidden Kidney and Leg Artery Disease
A large Chinese cross-sectional study of 3,000 patients with type 2 diabetes finds that diabetic retinopathy is strongly associated with ...
Rising RNA Signal in Blood May Track Diabetic Kidney Damage in Egyptian Patients
A new study of Egyptian patients with type 2 diabetes finds that serum levels of the long noncoding RNA PVT1 ...
ADAM17 Enzyme Drives Migration in Canine Mammary Tumor Cells, Study Finds
A new study in BMC Cancer shows that the protease ADAM17 is upregulated in aggressive canine mammary carcinomas and promotes ...
Lactate Tag on Histones Fuels Drug Resistance in Head and Neck Cancer
New research shows that CBP-driven histone H3K18 lactylation activates GLI2 transcription, promoting head and neck squamous cell carcinoma progression and ...
Self-Assembling Peptide Turns Tumor Cells Into Antibody Magnets for Cancer Immunotherapy
A receptor-triggered peptide self-assembly strategy converts monomeric hapten conjugates into multivalent antibody-recruiting fibrils on EGFR-positive tumor cells, driving potent complement-mediated ...
Myc’s Role in Lung Cancer Growth Through EGFR
Lung adenocarcinoma (LUAD) presents a significant challenge to clinicians and researchers alike, as the prognosis for patients diagnosed at late ...
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