Tag: Drug repurposing

Machine learning is accelerating target identification, toxicity prediction and drug repurposing, but researchers insist algorithmic discoveries still demand rigorous experimental ...

A comprehensive review finds that the lipid-lowering drug fenofibrate shows strong clinical evidence for slowing diabetic retinopathy and promising preclinical ...

Idiopathic pulmonary arterial hypertension (IPAH) has long puzzled physicians... The methodological architecture of the study deserves closer examination, because the ...

WEHI researchers have discovered that gamma delta T cells can recognise and kill small cell lung cancer, and that two ...

A new review in Molecular Cancer maps how approved drugs from outside oncology could be repurposed, under a strict mechanism-first ...

A machine learning framework called BioBombe maps the biological processes that cancers depend on for survival, revealing new vulnerabilities and ...

Chemists have converted the anti-inflammatory drug diflunisal into fluorinated biphenyl ureas that kill Mycobacterium kansasii at nanomolar-scale concentrations while leaving ...

CNIO researchers have identified a transient, drug-vulnerable proliferative pause in brain micrometastases that could allow metastasis to be eliminated before ...

A Nature Communications study shows that loss of the SWI/SNF subunit SMARCD1 drives clear cell renal cell carcinoma through a ...

Researchers report that the FDA-approved antibiotics doxycycline and methacycline selectively bind acetylated KLF5 and suppress prostate cancer bone metastasis by ...

New research shows that the diabetes drug metformin protects lymphatic vessels from mitochondrial damage caused by the chemotherapy agent 5-fluorouracil ...

University of São Paulo researchers found that fourteen derivatives of an anticancer compound kill Plasmodium falciparum at both the blood ...

Integrating single-cell and spatial transcriptomics, researchers identified a novel invasive-frontier fibroblast state and the multicellular community it defines, which independently ...

Researchers found that rabies virus hijacks the Cav1.2-KCa1.1 ion channel axis to enter cells, and that the FDA-approved calcium channel ...

Researchers report that the approved HIV protease inhibitor ritonavir binds the HCMV immediate-early protein IE1 and promotes its ubiquitin-proteasome-mediated degradation, ...

New research shows that pairing the decades-old antipsychotic chlorpromazine with the mitochondrial fission inhibitor mdivi-1 sharply boosts cancer cell death ...

Researchers in Taiwan mapped a 25-microRNA regulatory network driving radioresistance in head and neck cancer and used transcriptome-guided drug repurposing ...

A large target trial emulation found that cancer patients on SSRIs while receiving immune checkpoint inhibitors had significantly lower two-year ...

An integrated analysis of human genetics, patient-derived cell models and electronic health records has identified 19 Alzheimer's drug targets in ...

An integrated analysis of proteomic data from nearly 90,000 people, single-cell sequencing and molecular docking has identified seven high-confidence drug ...