A comprehensive review indicates that guideline-supported multicomponent delirium prevention and coordinated recovery provide the strongest clinical foundation for older orthopedic ...
A systematic review of 29 surgical trials found that sleep-promoting and circadian interventions were associated with lower postoperative delirium rates, ...
A comprehensive narrative review analyzes clinical trials and developmental pharmacology to evaluate the safety, efficacy, and limitations of opioid-free anesthesia ...
A retrospective single-center study found that adding low-dose dexmedetomidine to ciprofol was associated with fewer significant blood pressure drops and ...
A systematic review found intraoperative dexmedetomidine sedation was associated with lower postoperative delirium than propofol in elderly non-cardiac surgery patients, ...
A randomized controlled trial found that adding dexmedetomidine to a ropivacaine erector spinae plane block did not reduce chronic postsurgical ...
A systematic review and network meta-analysis revealed that commonly used sedatives provide no clear survival advantage in mechanically ventilated adults ...
A nested case-control study found that pre-existing sleep disturbance, recent daytime naps, and prolonged fasting were independently associated with sedation-related ...
A systematic review and meta-analysis of 98 randomized controlled trials found that dexmedetomidine and a combination of midazolam and ketamine ...
A comprehensive clinical review details how shifting from general anesthesia to monitored anesthesia care and advanced monitoring optimizes outcomes in ...
A study in mice reveals that dexmedetomidine sedation is neurophysiologically distinct from natural sleep, producing pronounced cortical spikes and altered ...
A narrative review evaluates preclinical evidence for pairing the anesthetic dexmedetomidine with biomaterial scaffolds to counter secondary spinal cord injury ...
A study finds patient-controlled sleep therapy with dexmedetomidine enhances glymphatic-related imaging markers in patients with comorbid insomnia and depression.
An updated meta-analysis indicates perioperative intravenous dexmedetomidine reduces postoperative delirium and nausea in older surgical patients while increasing bradycardia and ...
A retrospective cohort study of 82 infants found that a multimodal analgesia regimen combining sufentanil, esketamine, and dexmedetomidine was associated ...
A scoping review of 13 studies finds no standardised approach to agitation after traumatic brain injury, with olanzapine and valproic ...
A new editorial argues that recent large trials have failed to show broad benefits for the sedative dexmedetomidine, while suggesting ...
A mouse and cell study finds dexmedetomidine reduces doxorubicin- and trastuzumab-induced myocardial fibrosis by promoting Serpine1 and regulating the STAT3/Notch-1 ...
A single case report describes a 37-year-old woman with severe post-dural puncture headache whose pain resolved within 48 hours on ...
A study in Cell Death Discovery links perioperative destabilization of regulatory T cells to blood–brain barrier disruption through a β-catenin–tight ...
