HIT-HARD Trial Protocol Tests Short-Course High-Dose Antibiotics
The HIT-HARD trial protocol outlines a phase III study testing if short-course, high-dose beta-lactam therapy is non-inferior to conventional regimens ...
Tag: Clinical Trial Protocol
International Clinical Trial Evaluates Oral Bacterial Lysate for Preventing Infant Wheeze
A multicentre randomised trial is testing whether an oral bacterial lysate can reduce recurrent wheezing episodes in infants following hospitalisation ...
Phase II Protocol Evaluates Neoadjuvant Intraperitoneal Chemotherapy for Colorectal Peritoneal Metastases
A phase II multicentre study protocol evaluates the feasibility of combining neoadjuvant intraperitoneal irinotecan with systemic therapy prior to cytoreductive ...
Trial Protocol Evaluates Acupoint Stimulation For Preventing Postoperative Nausea In Gynecologic Surgery
A multicenter clinical trial protocol outlines a randomized factorial study evaluating whether transcutaneous electrical acupoint stimulation at the P6 acupoint ...
Trial Protocol Seeks to Cut Low-Value Prescribing in Older Adults
A new trial protocol in the Basque Health Service plans to test if pharmacist-led facilitation can enhance audit and feedback ...
Trial Protocol Tests Empagliflozin in Duchenne Cardiomyopathy
A new phase 2a trial protocol aims to evaluate the pharmacokinetics and safety of empagliflozin in children with Duchenne muscular ...
High-fibre, fermented-food diet trial will test gut-brain route to easing adult ADHD symptoms
A randomized controlled trial in Ireland will test whether a high-fibre, fermented-food diet targeting the gut microbiota can reduce ADHD ...
ACO-SWITCH Trial to Track Serum Transthyretin After Tafamidis-to-Acoramidis Switch
A newly published protocol details ACO-SWITCH, a phase 4 single-arm study that will measure serum transthyretin changes in 50 adults ...
Nanoparticle radiosensitizer to be tested with whole-brain radiotherapy in new phase II trial
A new phase II trial protocol will test whether AGuIX nanoparticles, already shown to be tolerated at 100 mg/kg in ...
First Immune-Modulating Drug Trial Targets Neuroinflammation in Prodromal Parkinson’s Disease
A published protocol details the first randomised, placebo-controlled trial testing whether the oral drug PXS-4728A reduces PET-measured brain neuroinflammation in ...
Randomized DSEE-CRC trial will test tumoroid-guided therapy in refractory metastatic colorectal cancer
The DSEE-CRC trial will randomize patients with chemotherapy-refractory metastatic colorectal cancer to tumoroid-guided therapy or standard trifluridine-tipiracil and bevacizumab.
Virtual Reality Mindfulness Study Tests Whether Children Can Use Operation Calm
A new Canadian protocol study will test whether children aged 6 to 17 can complete and tolerate a ten-minute virtual ...
PSMA-PRED protocol plans biomarker search for lutetium-PSMA treatment response
The French PSMA-PRED protocol plans to profile tumor DNA, RNA and methylation in 120 patients to identify candidate biomarkers associated ...
Protocol plans randomized comparison of kidney-protective drugs during HIPEC
A planned 90-patient randomized trial will compare cilastatin with sodium thiosulfate for preventing acute kidney injury during cisplatin-based HIPEC, but ...
Trial protocol tests two acupuncture techniques for post-stroke leg recovery
A 130-participant assessor-blinded trial in Tianjin will compare penetrating needling between two ankle acupoints with separate needling at the same ...
Shenqi Shiyiwei Granule for breast cancer related fatigue-centered symptom cluster: protocol of a multicenter randomized double-blind placebo-controlled trial
A planned multicenter trial will randomize 262 postoperative breast cancer survivors to Shenqi Shiyiwei Granule or placebo to test a ...
BELI(E)VE protocol evaluates belantamab mafodotin plus venetoclax in t(11;14)-positive relapsed or refractory multiple myeloma
The BELI(E)VE protocol describes a German phase I/IIa trial of belantamab mafodotin plus venetoclax, with or without dexamethasone, in t(11;14)-positive ...
Australia Launches Nationwide APRISE Surveillance Program to Detect Pancreatic Cancer Early in High-Risk Individuals
A new nationwide Australian study will follow people with inherited pancreatic cancer risk for up to ten years to determine ...
Ancient Herbal Formula Meets Modern Oncology in Landmark Gastric Cancer Trial
A twelve-hospital, double-blind, placebo-controlled trial in China will test whether the traditional herbal formula Yiqi Huayu Jiedu Decoction combined with ...
Introducing a New Gold Standard for Medication Safety in Breastfeeding
In a groundbreaking advancement poised to transform our understanding of medication safety during breastfeeding, researchers at Uppsala University, Sweden, are ...
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