MDK Identified as Key Mediator of Cisplatin Resistance in Ovarian Cancer
A new study identifies midkine as a key mediator of cisplatin resistance in ovarian cancer, linking it to the PI3K/AKT ...
Tag: cisplatin resistance
MTRF1 Reverses Bladder Cancer Cisplatin Resistance via Ferroptosis
A new study identifies MTRF1 as a key factor in reversing cisplatin resistance in bladder cancer by triggering ferroptosis through ...
LncPRESS1 Drives Breast Cancer Progression and Cisplatin Resistance
A new study in Cell Division reveals that the long noncoding RNA LncPRESS1 promotes breast cancer progression and cisplatin resistance ...
Transcription Factor TFAP2A Regulates FAM83A to Inhibit Ferroptosis in Lung Cancer
Researchers identified a molecular cascade in non-small cell lung cancer where the transcription factor TFAP2A promotes FAM83A expression to suppress ...
Study Links Evodiamine to Cisplatin-Resistant Lung Cancer Targets
An integrative study identifies Evodiamine as a potential multi-target therapeutic agent against cisplatin-resistant non-small cell lung cancer by targeting key ...
Targeting DNA Repair Genes Overcomes Cisplatin Resistance in Colon Cancer Organoids
Inhibition of specific DNA repair pathways restores cisplatin sensitivity and enhances cell death in TP53-deficient colon cancer organoids.
Notch ligand DLL1 shields ovarian cancer cells from ferroptosis, fueling cisplatin resistance
A preclinical study reports that the Notch ligand DLL1 activates an Nrf2/GPX4 antioxidant axis that suppresses ferroptosis and weakens cisplatin's ...
Cannabidiol Selectively Kills Cisplatin-Resistant Head and Neck Cancer Cells in Preclinical Study
A preclinical study reports that cannabidiol selectively impaired viability, migration, invasion, and clonogenic survival of cisplatin-resistant HPV-negative head and neck ...
Chaperonin Protein CCT2 Emerges as Key Driver of Aggressive Head and Neck Cancer and Cisplatin Resistance
New research shows that the chaperonin subunit CCT2 stabilizes the oncoprotein c-Myc to drive head and neck squamous cell carcinoma ...
Scientists Uncover How Oral Cancer Cells Outsmart Cisplatin by Blocking Ferroptosis
New research reveals that the secreted protein DKK1 helps oral squamous cell carcinoma resist cisplatin by keeping the SLC3A2 cystine ...
Low Oxygen Inside Tumors Fuels Cervical Cancer Growth and Cisplatin Resistance, Study Finds
Researchers at Chongqing Medical University report that hypoxia silences the tumor suppressor CCNDBP1 in cervical cancer, activating a USP11–Nrf2 antioxidant ...
Zinc Complexes Emerge as Safer Rivals to Platinum Cancer Drugs, Landmark Review Finds
A systematic review of 66 zinc(II) Schiff base complexes shows that octahedral geometry and red-shifted imine infrared signatures predict potent, ...
Scientists Uncover a Fat-Metabolism Switch That Fuels Esophageal Cancer and Blunts Chemotherapy
A new study shows that the transcription factor ELF4 activates the enzyme UGT8, reshaping sphingolipid metabolism to drive esophageal squamous ...
Evodiamine Targets Genes in Cisplatin-Resistant Lung Cancer
In a groundbreaking study that delves into the molecular mechanisms of chemotherapy resistance, researchers have unveiled promising insights into the ...
New lncRNA Drives Cisplatin Resistance in Lung Cancer
In an unprecedented breakthrough, researchers have uncovered a revolutionary molecular mechanism behind chemoresistance in non-small cell lung cancer (NSCLC), focusing ...
