CDKN3 in cancer: one phosphatase, many contradictory stories
A new narrative review argues that conflicting CDKN3 findings across cancers reflect incompatible evidence types, not a true molecular paradox.
Tag: chromosomal instability
Cancer cells ramp up transcription across the genome, review finds
A new review describes how global transcriptional upregulation, or hypertranscription, driven by oncogene-encoded transcription factors may contribute to chromosomal instability ...
Review Reframes MAD Genes as a Coordinated Genome Stability Axis in Cancer
A Molecular Cancer review redefines the MAD gene family as a unified HORMA-domain genome surveillance system linking spindle checkpoint control ...
When Healthy Cells Merge: Fusion Events Trigger Genome Chaos That May Ignite Cancer
New research shows that spontaneous fusion between non-malignant breast epithelial cells triggers catastrophic genomic instability, ploidy reduction and EMT-like traits, ...
Cancer’s Rogue DNA Can Backfire, Trapping Oncogenes in Micronuclei and Slowing Tumors
New research shows that damaged extrachromosomal DNA is trapped in transcriptionally silent micronuclei, impairing cancer cell fitness and predicting better ...
Plasma DNA Instability Signals Liver Cancer Spread
A groundbreaking prospective study published in BMC Cancer unveils a novel, ultrasensitive method for predicting microvascular invasion (MVI) in hepatocellular ...
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