Computational modeling and genomic mapping reveal how DNA mechanical properties and regulatory proteins jointly coordinate nucleosome positioning and co-transcriptional splicing ...
Time-resolved mapping in human monocytes reveals that early promoter-proximal vitamin D receptor binding establishes core gene activation before distal enhancers ...
Researchers reconstituted complex three-dimensional chromatin folding and topologically associating domains in a cell-free system using Drosophila syncytial embryo extracts.
Deleting the Tcra enhancer revealed that it selectively regulates two distant genes across a TAD boundary while leaving closer neighboring ...
A new spatial imaging technique called Epi-PHR maps combinations of epigenetic marks at high genomic resolution while preserving the three-dimensional ...
A computational reanalysis of public EBV data finds that promoters contacted by the viral EBER noncoding RNAs remain chromatin-accessible yet ...
A new BMC Biology study shows that chromosomal inversions in Anopheles mosquitoes reshape 3D genome folding and rewire enhancers near ...
A new spatial 3D genomics technology called SpaceA maps long-range chromatin interactions inside intact mouse embryo tissue and uncovers a ...
A massive Hi-C study across eight mouse strains shows that the strength of chromatin boundary insulation predicts how faithfully topologically ...
A new computational framework called DeCTCF uses AI-predicted epigenomic features to sort more than 236,000 CTCF binding sites into 20 ...
An Oxford-developed single-allele chromatin mapping platform called MCCv identifies causal noncoding variants in autoimmune disease and reveals that a neo-CTCF ...
A new review argues that host chromatin architecture and three-dimensional genome rewiring, not just HPV oncoproteins, stabilize malignant states and ...
Researchers have discovered that DNA methylation evicts the architectural protein CTCF from the HOXD locus, collapsing a chromatin loop that ...
A cross-species single-cell epigenome atlas shows that kidney disease accelerates epigenetic aging most dramatically in tubular epithelial cells, which lose ...
A new review argues that transcription occurs in multi-scale bursts shaped by DNA methylation, histone variants, modifications and enhancer looping, ...
In a groundbreaking study published in Nature Communications, Lee, Hwang, McRiley, and colleagues have unveiled an unprecedented single-nucleus atlas of ...
In a pioneering leap forward in cardiovascular genetics, researchers have unveiled the profound impact of chamber-specific chromatin architecture on the ...
In a groundbreaking study set to transform our understanding of gene regulation, researchers have introduced a novel sequencing technology called ...
In the earliest moments of mammalian life, a fascinating and intricate dance unfolds within the embryonic nucleus as the genome ...
