Blood Cholesterol Marker Flags Brain Injury Risk in Growth-Restricted Infants
A blood-based cholesterol metabolite, 24S-hydroxycholesterol, shows reduced levels in IUGR infants and predicts neurodevelopmental risk in new mouse and clinical ...
Tag: cholesterol metabolism
Computational study ranks Andrographis diterpenoids at the PCSK9–LDLR interface
A computational study of six Andrographis paniculata diterpenoids found that andrograpanin, though not the top docking scorer, engaged the broadest ...
R-propranolol shows strongest anti-angiogenic effect in infantile haemangioma cell model
In a three-dimensional laboratory model of infantile haemangioma endothelial cells, R-propranolol suppressed sprouting angiogenesis and angiogenic factor secretion more strongly ...
Pantethine supplement shows promise against psoriasis in mice and small trial
A vitamin B5 derivative called pantethine suppressed dendritic cell hyperactivation, prevented psoriasis in mice and improved symptoms in a small ...
Biomaterials Target Cholesterol Metabolism to Exploit Cancer Cell Vulnerabilities
A new review maps how biomaterials can exploit cholesterol metabolism in cancer while warning that most mechanistic claims remain unproven.
Chronic Demyelination Traps Microglia in a Lysosomal Cholesterol State
A Nature Neuroscience study in mouse models and human multiple sclerosis tissue identifies a pro-inflammatory microglial state marked by lysosomal ...
Lactate Fuels a Hidden Molecular Chain That Helps Liver Cancer Evade Immunity
A new study reveals how lactate-driven lactylation of histone and non-histone proteins in liver cancer activates a METTL3-FDFT1 cholesterol pathway ...
Cholesterol’s Hidden Geography: How Tumor Neighborhoods Fuel Resistant Prostate Cancer
A paired spatial multi-omics study of prostate cancer reveals that rising cholesterol during therapy tracks with castration resistance, as import-dominant ...
Tetrandrine Blocks SARS-CoV-2 via Cholesterol, IGF
In an era still grappling with the pervasive threat of SARS-CoV-2, the virus responsible for the devastating COVID-19 pandemic, the ...
