Scientists Report First Chemical Probes That Block CDCA7’s DNA Recognition
Structure-guided screening has yielded two compounds that selectively interfere with CDCA7 binding to hemi-methylated DNA, partially recapitulating phenotypes of CDCA7 ...
Tag: Chemical probes
Famed brain cancer drug turns out to hit a metabolic enzyme, not its intended target
A comprehensive chemical biology study shows that the celebrated KDM4 inhibitor QC6352 and its clinical analog zavondemstat kill glioblastoma stem ...
Mapping Arginine Reactivity Across the Human Proteome
In an unprecedented leap toward deciphering the complexities of protein chemistry, researchers have charted a comprehensive map of arginine reactivity ...
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