T-Cell IRG1-Itaconate Axis Inhibits Allergic Airway Inflammation
Researchers found that the intrinsic IRG1-itaconate axis in CD4+ T cells restrains allergic airway inflammation by dampening PI3K/Akt/mTOR signaling, with ...
Tag: CD4+ T cells
Oral Microbiome, Metabolites and Immune Signals Linked in Recurrent Mouth Ulcers
A small integrated study found that recurrent aphthous ulceration is associated with coordinated shifts in oral bacteria, serum metabolites and ...
Blood Lymphocyte Patterns Predict Relapse Risk in Treatment-Naïve Myositis Patients
A retrospective study of 126 treatment-naïve idiopathic inflammatory myopathy patients found that pre-treatment lymphocyte subset profiles differed across disease subtypes ...
DNA Methylation Test Matches Flow Cytometry for Measuring Immune Cells in Blood
A new study reports that quantifying immune cells from DNA methylation patterns matches clinical flow cytometry and CBC results within ...
Why Whooping Cough Is Coming Back: T Cells Hold the Answer
A new review explains how CD4+ T-cell responses differ between natural infection, whole-cell and acellular pertussis vaccines, and why this ...
Ancient Immune Checkpoint in Zebrafish Reveals How Bacteria Hijack T Cell Metabolism
Scientists studying zebrafish have identified a previously underappreciated immune checkpoint that appears to represent an ancient forerunner of the mammalian ...
Research report: Integrative transcriptomic and single-cell analyses link ENO1 to CD4+ T cell function and glycolysis-associated metabolism in systemic lupus erythematosus
An integrative analysis of bulk and single-cell transcriptomic data identifies ENO1 as a reproducibly upregulated metabolic factor associated with CD4+ ...
Monocytes, Not T Cells, Show Strongest Gene Disruption in Multiple Sclerosis
A reanalysis of bulk RNA-sequencing data from multiple sclerosis patients finds that CD14+ monocytes show the most extensive transcriptional and ...
CD4 T Cell Help Powers Immunotherapy Response in Tumors Lacking MHC-I
Mouse experiments show that CD4+ T cells license CD8+ T cells through CD40 signaling, enabling combination immunotherapy to eliminate mismatch ...
Rare Immune Deficiency Unmasked by Deadly Brain Infection in HIV-Negative Woman
A case report details how a 46-year-old HIV-negative woman with idiopathic CD4+ lymphocytopenia developed progressive multifocal leukoencephalopathy and died despite ...
New chimeric antibodies turn marmosets into a working KSHV infection model
Two newly developed mouse–marmoset chimeric monoclonal antibodies enabled controlled T cell depletion in common marmosets, revealing KSHV lytic replication and ...
Chemical Mouth Injury and Bacterial Infection Triggered Erythema Multiforme in an 11-Year-Old Boy
A case report describes an 11-year-old boy whose oral chemical injury and secondary Staphylococcus aureus infection led to erythema multiforme, ...
Gut Infections Leave Long-Lasting Immune Memory at the Brain’s Border
A mouse study shows that intestinal infections seed long-lived, antigen-specific memory CD4+ T cells in the dura mater, which can ...
Early Feeding After Gastrectomy Linked to Immune-Cell Preservation
A retrospective cohort study linked enteral nutrition within 24 hours of gastrectomy for gastric cancer with better preservation of selected ...
Six-Year Japanese Surveillance Finds Sustained HIV Suppression With Dolutegravir/Rilpivirine
A six-year Japanese post-marketing study found sustained HIV suppression and stable CD4+ T-cell counts in a small cohort that switched ...
Review maps cell-specific MAVS and inflammasome signaling in HIV-1
A review finds that HIV-1 suppresses MAVS-dependent antiviral signaling in myeloid cells while distinct IFI16 and CARD8 pathways can promote ...
Screening-defined neurocognitive impairment frequent in vulnerable Amazonian HIV cohort
A cross-sectional Manaus study classified 67.6% of treated adults living with HIV as having screening-defined neurocognitive impairment, while associations with ...
Defective HIV proviruses reprogram T cells at selected integration sites
A cellular study shows how transcriptionally active defective HIV proviruses can reprogram CD4 T cells through integration-site-specific effects on host ...
sncRNA signatures underlying HIV-1 restriction in elite controllers
A comparative CD4+ T-cell study linked elite control of HIV-1 to reduced miR-99b-5p and miR-125a-5p, whose inhibition modestly reduced viral ...
Low CD4+ T-Cell Counts Track With Worse Tic Severity in Children
A cross-sectional study of 41 newly diagnosed children found that lower peripheral CD4+ T-cell counts were associated with higher tic ...
POPULAR NEWS
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Chinese Cancer Association issues unified guideline for tumor-related lung injury care
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Modeling Reveals How Silica Gold Nanoparticles Reshape Optical Energy and Fields
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Intravenous Iron Formulations Spur Divergent Muscle Recovery in Iron Deficiency Anaemia
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Pararectal Leiomyosarcoma Diagnosed After Laparoscopic Hysterectomy Without Morcellation