Tag: cancer stem cells

LF3 inhibited Wnt/β-catenin signaling and restored 5-fluorouracil sensitivity in a preclinical HCT-116 cell model of long-term chemotherapy resistance.

A 2026 commentary proposes that metabolic plasticity, stromal reprogramming and immune-metabolic competition create an adaptive tumor ecosystem that can promote ...

A review finds that miR-125b, miR-375 and miR-451 are linked to breast cancer chemoresistance through distinct, context-dependent mechanisms that require ...

A new review argues that epigenetic plasticity in drug-tolerant persister cells, not fixed cancer stem cell identity, may explain relapse ...

New research from Montreal reveals that the sorting receptor SORT1 links lipid remodeling, stemness and drug resistance in 3D glioblastoma ...

A new review argues that proteases drive chemoresistance through drug transport, matrix remodeling, and cell death signaling, and that precision-targeted ...

A new review highlights how induced pluripotent stem cells are being engineered into immune cells, cancer vaccines, and tumor models ...

A new review in Molecular Biology Reports maps how the apple-skin compound ursolic acid switches on cancer cell death, silences ...

A new study shows that sulforaphane from cruciferous vegetables suppresses NDMA-induced liver cancer stem cell properties by restoring the tumor-suppressive ...

The journal Pathology & Oncology Research has retracted a 2018 osteosarcoma study after the authors reported improper image cropping, with ...

A new review in Molecular Cancer maps how approved drugs from outside oncology could be repurposed, under a strict mechanism-first ...

New research shows that triple-negative breast cancer cells rely on shared DNA damage tolerance enzymes such as POLζ and CHK1 ...

Researchers report that cigarette smoke drives bladder cancer aggressiveness through exosome-delivered circ55033, which sponges miR-1286 to promote EMT and cancer ...

A new review in Molecular Cancer reframes radioresistance as an ecosystem-level phenomenon in which plastic residual tumor cells survive radiation ...

A new review explains how tumor cells reversibly switch identities through epigenetic and microenvironmental programs, driving metastasis and therapy resistance.

Researchers in China have shown that the deubiquitinating enzyme USP45 promotes hepatocellular carcinoma progression by removing K48-linked ubiquitin chains from ...

In the realm of oral health, the intricate relationship between tumor microenvironments and the recruitment of cancer stem cells has ...

In a groundbreaking study led by researchers Gong, Lp., Shao, Yt., and Du, Y., the intricate world of exosomal circular ...

In a pioneering breakthrough that could redefine therapeutic strategies for one of the most aggressive brain cancers, glioblastoma, researchers have ...

In the relentless pursuit of more effective and less toxic cancer treatments, natural compounds have continually offered promising avenues for ...