Phase Separation Is an Evolvable Trait, Argues New Evolutionary Framework
A new perspective argues that liquid–liquid phase separation should be studied as an evolvable molecular phenotype shaped by natural selection.
Tag: Biomolecular condensates
Crowded molecular environments steer synthetic DNA droplet self-assembly
Macromolecular crowding with polymers such as PEG promoted the formation of synthetic DNA nanostar droplets and allowed researchers to control ...
Phase-Separating Condensates Emerge as Drivers of Glioblastoma Progression and Drug Resistance
A review in Acta Neuropathologica Communications describes how aberrant liquid-liquid phase separation may drive glioblastoma progression and therapy resistance, and ...
How Molecular Flux and Rigid β Motifs Drive Fibril Growth at Condensate Interfaces
New simulations reveal that rigid β-prone motifs and the rate of molecular delivery jointly determine whether aging condensate interfaces spread ...
RNA Molecules Found to Drive Aggressive Leukemia Through Oncocondensates
Vienna researchers developed the bicon-seq method and discovered that the long non-coding RNA Gas5 is a functional component of leukemia-driving ...
Plants Build Their Own Sunscreen From Protein Condensates Under Intense Light
A Nature Plants highlight describes how singlet oxygen triggers MBS1 protein condensates that shield chloroplasts from excess light, and how ...
Computational Microscope Opens a New Window on Chromatin Folding
An international team has developed OpenCGChromatin, an open-source simulation tool that acts as a computational microscope to reveal how chromatin ...
Cell Nucleus Inspires DNA-Based Computer Chip Innovations Through Molecular Biomimetics
In the intricate world of cellular biology, the compact structure of human DNA presents both a marvel and a challenge. ...
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