CurvEdgeNet Predicts CircRNA-Disease Links Using Network Geometry
A new computational framework called CurvEdgeNet uses Ollivier-Ricci curvature to predict circRNA-disease associations with high accuracy on three benchmark datasets.
Tag: biomarker discovery
AI Models Show Promise in Pancreatic Cancer Diagnosis and Biomarker Discovery
A review in Cell Division evaluates AI and machine learning models for pancreatic cancer diagnosis, highlighting their high reliability in ...
GallMine Knowledgebase Centralizes Molecular and Clinical Data on Gallbladder Cancer
Researchers have developed GallMine, a unified repository integrating multi-omics datasets and published literature to advance computational analysis and therapeutic discovery ...
Machine learning sharpens leukemia diagnosis but waits on rigorous validation
A literature review finds that machine learning and bioinformatics have improved AML classification and risk stratification, but clinical implementation remains ...
Proteomic signatures linked to rapid antibody waning in older vaccinated adults
A nested case-control study associated distinct serum protein trajectories with rapid SARS-CoV-2 IgG waning after breakthrough infection in older vaccinated ...
Pooled healthy-person urine reveals urinary N-glycan diversity by reversed-phase LC/MS/MS
A reversed-phase LC/MS/MS workflow resolved diverse N-glycan isomers in pooled healthy-person urine and created a reference dataset to support future ...
Public-data reanalysis identifies cell-cycle signal in sinonasal cancer
A public-data reanalysis identified broad tumor-normal gene-expression changes in sinonasal squamous cell carcinoma and nominated four preliminary candidate biomarkers supported ...
Explainable AI prioritizes serum microRNAs for pancreatic cancer detection
A retrospective analysis of 1,101 serum samples used explainable artificial intelligence to prioritize circulating microRNAs that distinguished pancreatic cancer from ...
Network and cell study links carboplatin to four melanoma targets
Network analysis and B16F0 cell experiments linked carboplatin with CDKN1A, BRCA1, PTEN and AKT1 in melanoma, without establishing clinical benefit.
Singapore’s A*STAR and HistoIndex Join Forces to Speed Fibrosis Drug Development
Singapore's A*STAR has signed a Memorandum of Understanding with AI digital pathology firm HistoIndex to quantitatively evaluate preclinical therapeutic candidates ...
New Python Package Puts Biomarker Discoveries to the Test Before They Reach the Clinic
A new open-source Python package called ROOFS benchmarks multiple feature selection methods on a researcher's own data, evaluating predictive performance ...
ProteoBoostR: Revolutionizing Clinical Proteomics with AI
In the realm of clinical proteomics, innovative tools are crucial for harnessing the vast amounts of proteomic data generated in ...
Exploring the Genomic Features of Endometrial Polyps
In a groundbreaking study that could change our understanding of gynecological health, researchers have delved into the genomic landscape of ...
Unraveling Small-Cell Lung Cancer: A Multi-Omic Approach
In a groundbreaking study, researchers have conducted a comprehensive multi-omic profiling of small-cell lung cancer (SCLC), revealing crucial insights into ...
Innovative Frameworks Boost Extracellular Vesicle Biomarker Discovery
The intersection of artificial intelligence (AI) and extracellular vesicle (EV) biomarker discovery represents an exciting frontier in biomedical research, promising ...
Revolutionary Method Enhances Proteomic Profiling of EVs
In the ever-evolving field of proteomics, researchers are continuously seeking innovative methodologies to enhance biomarker discovery. Recent advancements have spotlighted ...
Metabolome Tracking from Pregnancy Predicts Childhood Disorders
In a groundbreaking longitudinal study set to transform our understanding of neurodevelopmental disorders, researchers have meticulously charted the metabolomic landscape ...
Plasma Protein Profiling Detects Cancer in Symptomatic Patients
In a groundbreaking advancement for cancer diagnostics, researchers have unveiled a plasma protein profiling technique capable of predicting cancer in ...
Proteome Atlas Unveils Diabetic Retinopathy Risks
In a groundbreaking study that promises to reshape our understanding of diabetic retinopathy, researchers have unveiled an unprecedented proteome atlas ...
Microsampling Advances in Mass Spectrometry Proteomics
In the rapidly evolving field of proteomics, researchers are continuously seeking innovative techniques to enhance sensitivity and efficiency in biomarker ...
