Tag: Alzheimer&#8217;s disease

A landmark autopsy study of 2,550 brains shows APOE-ε4 drives medial temporal tau through amyloid-β while women's tau burden persists ...

Multimodal AI in Mental Health Care Leans Heavily on a Single Dataset, Review Finds

A scoping review of 19 studies finds that multimodal AI fusing raw images with non-image data in mental and cognitive ...

The Golgi Apparatus Emerges as a Hidden Driver of Alzheimer’s Disease

A new review argues that the long-overlooked Golgi apparatus, supported by human genetic, proteomic, and lipidomic evidence, may be a ...

Two Separate Brain Gradients Reveal How Aging and Alzheimer’s Reshape Connectivity

A large two-cohort neuroimaging study shows that aging and Alzheimer's disease reorganize brain functional connectivity along two distinct cortical gradients, ...

Massive single-nucleus atlas reveals how genetic risk for brain disease acts cell by cell

A single-nucleus atlas of 5.6 million brain cells from 1,384 donors maps cell-type-specific genetic regulation underlying Alzheimer's disease, schizophrenia and ...

Ancient Chinese Formula Decoded: Machine Learning Reveals How Bushen-Yizhi May Fight Alzheimer’s

Researchers combined mass spectrometry, machine learning and animal experiments to reveal how the traditional Chinese formula Bushen-Yizhi protects against Alzheimer's-like ...

Dementia May Not Be a Brain Disease at All, NIH Scientists Argue

NIH researchers argue that dementia may be the late-life manifestation of a systemic failure of energy regulation rather than a ...

Genes, Big Data and a Protective Mutation Point to New Alzheimer’s Drug Targets

An integrated analysis of human genetics, patient-derived cell models and electronic health records has identified 19 Alzheimer's drug targets in ...

Anesthesia and Surgery Rewire the Alzheimer’s Brain Differently, Mouse Study Suggests

A new exploratory RNA sequencing study finds that the hippocampal response to anesthesia and surgery is directionally inverted in 5xFAD ...

Brain Scans and Mitochondrial DNA Offer Clues to Maternal Alzheimer’s Risk

Machine learning of structural MRI and mitochondrial haplogroups can moderately predict a maternal family history of Alzheimer's disease, with precuneus ...

New AI Reads Brain Scans Four Ways to Spot Alzheimer’s Stages and Know When It Is Unsure

A new multi-stream deep learning framework called MS-AtroNet combines convolutional, state-space, wavelet, and evidential components to classify Alzheimer's MRI slices ...

Hidden RNA Switches in the Human Brain Reveal New Genetic Routes to Alzheimer’s and Parkinson’s Disease

A single-cell atlas of alternative polyadenylation across two million human brain cells reveals a hidden genetic regulatory layer that explains ...

Protective APOE2 Gene Softens the Damage Wrought by Alzheimer’s Risk Gene APOE4

New research in mice shows that the protective APOE2 allele actively counteracts amyloid plaque buildup, microglial dysfunction, and proteomic changes ...

Graph-Based AI Reads microRNA Networks to Spot Alzheimer’s Early

A new graph-based machine learning method called GraphiRNA models the relationships among microRNAs, including negative correlations, to diagnose Alzheimer's disease ...

Vienna Prepares for EANM’26 as Radioactive Drugs Reshape Modern Medicine

Around 10,000 experts from 138 countries will gather in Vienna from October 17 to 21, 2026, for EANM'26 as theranostics, ...

Tau Takes Center Stage: New Review Maps the Phosphorylation Network Driving Alzheimer’s Disease

A new review in the Journal of Translational Medicine reframes tau phosphorylation as a dynamic hub within a multi-scale network ...

Deaths Involving Both Alzheimer’s and Cancer Decline Slightly Yet Grow in Number Among Older Americans

A 25-year national analysis finds that age-adjusted U.S. death rates involving both Alzheimer's disease and cancer among adults aged 65 ...

Fats in the Brain: How Lipid Imbalance May Drive Alzheimer’s Before Symptoms Appear

A new review in BMC Medicine argues that disrupted lipid homeostasis is an early, measurable, and modifiable driver of brain ...

Sweet Tooth, Faster Aging: Dietary Preferences Linked to Dementia Risk

A large UK Biobank cohort study finds that a sweet-tooth dietary preference profile is associated with sharply higher dementia risk, ...

AI Maps the Hidden Diversity of Amyloid Plaques Across the Alzheimer’s Brain