Tag: Age-related macular degeneration

Dr. Johnson V. John has received an NIH R56 grant to develop and evaluate 3D-bioprinted retinal grafts in preclinical models ...

A hypothesis-generating review proposes that the mitochondrial contact site and cristae organizing system acts as a structural checkpoint linking crista ...

A comparative transcriptomic review reveals six shared glial signaling pathways linking neuroimmune and metabolic reprogramming in Alzheimer’s disease and age-related ...

A scientific review details how epigenetic mechanisms influence complement system activity and tissue vulnerability across context-dependent stages of biological aging.

A prospective study of 86,271 UK Biobank participants found that concentrating moderate-to-vigorous physical activity into one or two days is ...

A prospective UK Biobank study links prefrailty and frailty to higher incidence of four major ocular diseases, mediated in part ...

A large prospective study identified prediagnostic plasma proteomic patterns and highlighted NECTIN2 as a key candidate in age-related macular degeneration.

A retrospective cohort study of five hundred macular degeneration patients found that type 4 macular neovascularization occurred in two percent ...

Deep learning models can detect geographic atrophy on retinal OCT scans with high accuracy but still struggle to reliably separate ...

A multi-omics Mendelian randomization study identified 22 plasma proteins associated with age-related macular degeneration, highlighting four high-confidence therapeutic candidates.

A cross-sectional analysis of 4,748 adults found that lipid and inflammatory biomarkers showed only nominal or model-dependent associations with age-related ...

A new review argues that Müller glia, the retina's dominant support cells, actively shape retinal disease progression and may offer ...

An integrative genomic and proteomic study identified seven new genetic loci and 23 genetically supported plasma proteins for age-related macular ...

A phenotype-exome analysis of two Saudi siblings with neovascular age-related macular degeneration identified shared rare retinal variants, including HMCN1 p.Asn2980Thr, ...

A new review finds that while AREDS formulations remain the only well-established nutritional therapy for retinal disease, NAD+ boosters, citicoline, ...

A study of 792,084 people of European ancestry combined prospective and genetic analyses and linked genetically elevated eosinophil counts to ...

A study links the high-risk CFH Y402H genotype to granzyme B activity, reduced vitronectin and membrane attack complex deposition in ...

A small randomized trial sub-study found no significant individual-gene changes after 18 months of metformin in older adults with age-related ...

New cost-of-illness analyses reveal that age-related macular degeneration and diabetic macular edema cost Bulgaria €545.7 million between 2017 and 2023 ...

A comprehensive review finds that the lipid-lowering drug fenofibrate shows strong clinical evidence for slowing diabetic retinopathy and promising preclinical ...