• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Monday, January 30, 2023
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

Scientists discover secreted protein helps both repair and grow muscles

Bioengineer by Bioengineer
January 14, 2023
in Biology
Reading Time: 3 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Tokyo, Japan – Scientists from Tokyo Metropolitan University have discovered that a protein called platelet-derived growth factor subunit B (PDGF-B) is continuously secreted from skeletal muscle cells and helps to repair muscles by encouraging myoblasts (muscle stem cells) to proliferate. Unexpectedly, they found that PDGF-B also helps muscle fibers grow. They confirmed this corresponded to fibers contracting more strongly. Their findings promise game-changing therapies for treating muscular atrophy and injury.

How the myokine PDGF-B impacts cellular processes in skeletal muscle.

Credit: Tokyo Metropolitan University

Tokyo, Japan – Scientists from Tokyo Metropolitan University have discovered that a protein called platelet-derived growth factor subunit B (PDGF-B) is continuously secreted from skeletal muscle cells and helps to repair muscles by encouraging myoblasts (muscle stem cells) to proliferate. Unexpectedly, they found that PDGF-B also helps muscle fibers grow. They confirmed this corresponded to fibers contracting more strongly. Their findings promise game-changing therapies for treating muscular atrophy and injury.

Myokines are small proteins secreted by skeletal muscle cells. They have a wide range of functions and may act on cells both near and far to where they are made. A comprehensive picture of how myokines affect cellular processes is far from clear, but it is believed that they play an important role in exercise-related bodily functions, particularly the maintenance of muscle tissue.

A team led by Associate Professor Yasuko Manabe at Tokyo Metropolitan University has been studying how myokines affect the behavior of muscle cells. Through extensive experiments, they found that a myokine known as platelet-derived growth factor subunit B, or PDGF-B, is secreted by skeletal muscles in a constitutive way i.e. without any stimulus. To understand what role it plays, they took myoblasts, precursor cells which go on to differentiate into muscle fibers, and exposed them to PDGF-B. They were able to clearly show that PDGF-B induced greater proliferation of myoblasts.

Curiously, they also found that PDGF-B impacted cells which had already differentiated. They took myotubes, a developmental stage of muscle fibers, and exposed them to the same myokine. Myotubes treated in this way exhibited significantly more maturation, visibly increasing in diameter under microscope observation. They also expressed more Myosin Heavy Chain, a key part of the protein structure of myosin, the molecular motor responsible for muscle contraction. Using a recently developed technique based on observing how myotubes react to an electric pulse, this was shown to directly correspond to increased contractile strength. Thus, PDGF-B not only helps make more muscle, but makes them stronger. But this doesn’t mean both processes are accelerated in a haphazard manner. They noticed subtle differences in PDGF-B signaling pathways between myotubes and myoblasts; the team believe these differences may be involved in cells switching from a proliferating phase to one where they are maturing.

The team’s work shows clearly that PDGF-B is involved in muscle regeneration and constitutes a big leap forward for developing effective treatments for muscle injury and atrophy as well as regimens for improving muscle performance.

This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grants-in-Aid for Scientific Research [Grant Number JP 17H02159, JP 26242068 and 18H04086], the Promotion of Science Funding Program for Next Generation World-Leading Researchers [JSPS NEXT Program Number LS102], the TMU strategic research fund for innovative research projects and a Tokyo Metropolitan Government Advanced Research Grant [R2-2].



Journal

Biochemical and Biophysical Research Communications

DOI

10.1016/j.bbrc.2022.11.085

Article Title

PDGF-B secreted from skeletal muscle enhances myoblast proliferation and myotube maturation via activation of the PDGFR signaling cascade

Article Publication Date

13-Dec-2022

Share12Tweet8Share2ShareShareShare2

Related Posts

A clump of sea campions next to some thrift or sea pinks.

Ancestral variation guides future environmental adaptations

January 27, 2023
Motile Sperm and Frequent Abortions in Spreading Earthmoss

Motile sperm and frequent abortions in spreading earthmoss

January 27, 2023

A transnational collaboration leads to the characterization of an emergent plant virus

January 26, 2023

Study shows that bioprinted artificial skin can be used in cosmetics and drugs testing

January 26, 2023

POPULAR NEWS

  • Jean du Terrail, Senior Machine Learning Scientist at Owkin

    Nature Medicine publishes breakthrough Owkin research on the first ever use of federated learning to train deep learning models on multiple hospitals’ histopathology data

    64 shares
    Share 26 Tweet 16
  • First made-in-Singapore antibody-drug conjugate (ADC) approved to enter clinical trials

    58 shares
    Share 23 Tweet 15
  • Metal-free batteries raise hope for more sustainable and economical grids

    41 shares
    Share 16 Tweet 10
  • One-pot reaction creates versatile building block for bioactive molecules

    37 shares
    Share 15 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

People with arthritis 20% less likely to be in work

A fairy-like robot flies by the power of wind and light

UK’s Overseas Territories at ongoing risk from wide range of invasive species

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 43 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In