Researchers Say Earlier Inflammasome Framework Anticipated Clonal Thrombo-Inflammation Model in Myeloproliferative Neoplasms

A correspondence published in Clinical and Experimental Medicine argues that a recently proposed model of clonal thrombo-inflammation in myeloproliferative neoplasms overlooks earlier work by the same authors that anticipated several of its central elements. Alessandro Lucchesi and Mariasanta Napolitano write that a model put forward by El-Sehrawy and colleagues, organised around the inflammasome, clonal stability and a multi-compartmental thrombotic niche, was addressed in two reviews their group published in 2021, neither of which is cited in the newer publication.

According to the correspondence, the first of the earlier reviews set out the pathogenetic role of the NLRP3 and AIM2 inflammasomes and their link to hypercoagulable states. The second formalised the vascular consequence of this process as the Circulating Wound, described as a self-sustaining lesion in which tissue-factor-rich clonal platelets, thrombin generation, protease-activated receptor signalling and TGF-β crosstalk reinforce one another.

The authors state that this coagulative arm is absent from the more recent model. They argue that the difference matters for the therapeutic reading of the framework, since the thrombotic circuit they described treats the vascular lesion as a mutually reinforcing loop rather than as separate compartments.

To support the earlier formulation, the correspondence summarises experimental findings from 53 therapy-naive patients with myeloproliferative neoplasms. The letter sets out where the two accounts diverge and why, in the authors’ view, that divergence bears on how the model should be interpreted clinically.

The piece is published as an open-access correspondence rather than as an original research article, so its claims rest on the prior reviews and the previously reported patient findings rather than on new data presented here.

Subject of Research: A correspondence highlighting an earlier inflammasome and thrombosis framework for myeloproliferative neoplasms

Article Title: Inflammasome, clonal stability and the thrombotic circuit in myeloproliferative neoplasms: an antecedent framework

Article References: Lucchesi, A., & Napolitano, M. (2026). Inflammasome, clonal stability and the thrombotic circuit in myeloproliferative neoplasms: an antecedent framework. Clinical and Experimental Medicine, 26(1), Article 356. https://doi.org/10.1007/s10238-026-02343-9

Image Credits: AI Generated

DOI: 10.1007/s10238-026-02343-9

Keywords: myeloproliferative neoplasms, inflammasome, NLRP3, AIM2, thrombo-inflammation, clonal stability, Circulating Wound, thrombosis, tissue factor, TGF-beta, correspondence, clonal