• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Thursday, August 7, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Chemistry

Repeat vape aerosol exposure causes minimal damage to lung tissue compared to cigarettes

Bioengineer by Bioengineer
May 5, 2021
in Chemistry
Reading Time: 4 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

How does vape aerosol affect lung cells over time? Scientific Digital Communications Editor Arran Frood details the latest research findings at Imperial Brands

IMAGE

Credit: Imperial Brands

5 May 2021, Bristol – In one of the most advanced applications of in-vitro 3D human lung models in vape research to date, a new peer-reviewed Imperial Brands study shows that, unlike combustible cigarette smoke, blu aerosol had little to no impact on numerous toxicological endpoints under the conditions of test using laboratory models.

Published in the journal Current Research in Toxicology, the experiments compared the toxicological responses of an in vitro 3D lung model (MucilAir™ from Epithelix) after repeated exposure to undiluted whole blu aerosol (1.6% tobacco flavour) or diluted whole cigarette smoke (3R4F Kentucky Reference) over a 28-day period.

After repeatedly exposing the model to smoke or aerosol from each product for four weeks, scientists assessed the biological activity of the 3D lung tissue model against five endpoints related to respiratory function:

  • Cytotoxic response (general toxicity to cells or tissue)
  • Barrier integrity (measuring the intactness of tissue structure )
  • Immunohistochemistry (general assessment of tissue structure)
  • Cilia beat frequency and active area (detecting abnormal lung cell function)
  • Pro-inflammatory response (identifying lung tissue inflammation)

This is the first peer-reviewed vaping study evaluating repeated whole cigarette smoke and whole aerosol exposure to a 3D lung model (at the air liquid interface) for this extended 28-day time period.

The use of a 3D lung model and extending the exposure scenario produced a more clinically relevant setup than previous applications, because the model is a closer representation of how the human lung is exposed to aerosol or smoke.

The Toxicity Testing in the Twenty-First Century (TT21C) driven study reinforces Imperial Brands commitment to using advanced 3D tissue models and cellular assays to as part of a global movement to reduce industry reliance on in-vivo (animal) experiments. (Imperial does not test any products on animals, unless formally required to do so by governments or recognised regulatory authorities. See our Position here.)

Results consistent with previous findings

Correlating with Imperial’s previous published applications of using a similar method, in the previous study an acute exposure to undiluted whole vape aerosol showed similar biological impact to the lung cell model as humidified air under the experimental conditions. However, diluted combustible cigarettes smoke elicited a significant dose-dependent response in all measured endpoints listed above.

As expected, in the present repeated exposure study, cigarette smoke produced a significant and dose-dependent biological response against all endpoints as the puff number was increased. “Cytotoxicity and inflammatory markers were all elevated in cigarette smoke,” said Fan Yu, Pre-Clinical Toxicologist at Imperial Brands and corresponding author. “Likewise, diluted cigarette smoke disrupted normal cilia beat function, cell barrier integrity, as well as tissue structure.”

At each puff dose, undiluted blu aerosol contained at least seven times more nicotine relative to cigarette smoke, but for all endpoints elicited no statistically significant difference with the negative control exposed only to humidified air. “Our results suggest nicotine is not the driver of the model’s cytotoxic response to cigarette smoke,” Yu explained. “More likely it is the many toxicants created through burning tobacco causing the responses that are absent, or substantially reduced, in vape aerosol.”

The study is further evidence that vaping may have significant harm reduction potential compared to combustible cigarettes for adult smokers who would otherwise continue to smoke.

“For adult smokers who are uninterested or unwilling to stop smoking, this study adds to a growing body research demonstrating Next Generation Products such as vapes offer a potentially reduced harm alternative if adult smokers choose to transition to these products,” said Dr Grant O’Connell, Head of Tobacco Harm Reduction Science.

He added: “To ensure adult smokers are fully informed of the scientific evidence base underpinning NGPs , we urge regulators, policy makers and media alike to recognise and communicate the scientific evidence, such as that presented here, as well as many other findings in the literature, and support a role for high quality, scientifically substantiated products in maximising tobacco harm reduction.”

###

See release on IMB Science website: https://imperialbrandsscience.com/timeline/repeated-exposure-to-vape-aerosol-causes-minimal-damage-in-human-lung-tissue-lab-model-compared-to-cigarette-smoke/

Read the full study here: https://www.sciencedirect.com/science/article/pii/S2666027X21000098?via%3Dihub

You are free to share this content with credit to Imperial Brands under a Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) license: https://creativecommons.org/licenses/by-nd/4.0/

Media Contact
Arran Frood
[email protected]

Original Source

https://imperialbrandsscience.com/timeline/repeated-exposure-to-vape-aerosol-causes-minimal-damage-in-human-lung-tissue-lab-model-compared-to-cigarette-smoke/

Related Journal Article

http://dx.doi.org/10.1016/j.crtox.2021.02.004

Tags: BiochemistryBiologyCell BiologyPharmaceutical SciencesPhysiologySmoking/TobaccoToxicology
Share12Tweet8Share2ShareShareShare2

Related Posts

blank

Scientists Develop Technique to Halt Ultrafast Silicon Melting with Precision Laser Pulses

August 7, 2025
blank

Breakthrough in Green Chemistry: Efficient Low-Temperature Oxidation Makes Processes Cleaner, Cooler, and More Affordable

August 7, 2025

Chiral Induction in Metal-Containing Dyes Achieved Through Simple Encapsulation

August 7, 2025

Exploring the Limits of Nuclear Stability: Multi-Step Fragmentation of High-Energy Projectiles in Thick Targets

August 7, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Neuropsychiatric Risks Linked to COVID-19 Revealed

    75 shares
    Share 30 Tweet 19
  • Overlooked Dangers: Debunking Common Myths About Skin Cancer Risk in the U.S.

    61 shares
    Share 24 Tweet 15
  • Predicting Colorectal Cancer Using Lifestyle Factors

    46 shares
    Share 18 Tweet 12
  • Modified DASH Diet Reduces Blood Sugar Levels in Adults with Type 2 Diabetes, Clinical Trial Finds

    41 shares
    Share 16 Tweet 10

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

How Ingredients Affect Tomato Ketchup’s Water Mobility

Tackling Pediatric Anemia in Asia’s Low-SDI Regions

Duloxetine Blocks Breast Cancer via AKT and Apoptosis

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.