• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Wednesday, September 10, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Probiotic Lactobacillus acidophilus shows promise for treating inflammatory bowel disease and other

Bioengineer by Bioengineer
April 20, 2021
in Health
Reading Time: 2 mins read
0
IMAGE
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Probiotic strain LA1 has a therapeutic effect that both prevents and treats intestinal inflammatory disorders caused by “leaky gut,” report researchers in The American Journal of Pathology

IMAGE

Credit: Rana Al-Sadi, PhD

Philadelphia, April 20, 2021 – Intestinal epithelial tight junctions (TJs) act as a functional and structural barrier against harmful antigens that promote intestinal inflammation in inflammatory bowel disease (IBD) and other inflammatory conditions of the gut. A defective intestinal TJ barrier, sometimes known as “leaky gut,” plays an important role in exacerbating and prolonging intestinal inflammation. New research reported in The American Journal of Pathology, published by Elsevier, shows that the probiotic Lactobacillus acidophilus (L. acidophilus) strain known as LA1 can generate a rapid and sustained enhancement of this defective intestinal barrier and effectively treat intestinal inflammation by preserving and restoring the intestinal barrier.

The use of probiotics has emerged as a therapy for a number of intestinal disorders, including IBD and necrotizing enterocolitis; however, specific probiotic bacteria with true beneficial effects on intestinal disease need to be identified. In this study researchers used high-throughput screening to assess over 20 probiotic bacteria to determine their ability to increase intestinal barrier function, using both a cell culture model of the intestinal epithelial lining and live mice.

The probiotic bacterial species L. acidophilus, specifically the LA1 strain, produced a rapid and marked increase in intestinal TJ barrier; other strains within L. acidophilus had no effect. The researchers found that this particular strain interacted with intestinal cells in a unique way to activate pathways that tightened the intestinal barrier, treating intestinal inflammation. It attaches to the intestinal epithelial membrane surface by directly interacting with the toll-like receptor-2 complex, which alerts the intestine to trigger an immune response.

The researchers also performed in vivo proof-of-concept studies in live mice to investigate the effect of LA1 and another strain, LA3, in the enhancement of mouse intestinal barrier and the therapeutic efficacy of LA1 in maintaining intestinal barrier and protecting against induced colitis. They found that LA1, but not LA3, caused rapid and marked enhancement of small intestine and colonic epithelial barrier in mice. Treatment studies after the onset of colitis found that LA1 was also effective in the healing of intestinal barrier and colitis.

“Our data indicate that LA1 is able to prevent colonic inflammation formation and promote colitis healing,” said lead investigator Thomas Ma, MD, PhD, Penn State College of Medicine, Hershey Medical Center, Hershey, PA, USA. “The implications of the present findings are that this bacterial strain can be used in a wide variety of intestinal permeability disorders, including IBD, coeliac disease, alcoholic liver disease, non-alcoholic fatty liver disease, and necrotizing enterocolitis, to treat inflammation associated with the leaky gut.”

L. acidophilus is found in various brands of yogurt including Chobani, Dannon, Siggi’s, Stonyfield, and Yoplait.

###

Media Contact
Eileen Leahy
[email protected]

Related Journal Article

http://dx.doi.org/10.1016/j.ajpath.2021.02.003

Tags: BacteriologyCell BiologyGastroenterologyMedicine/HealthNutrition/Nutrients
Share13Tweet8Share2ShareShareShare2

Related Posts

Next-Generation Wearable Pressure Sensors Inspired by Cat Whiskers Deliver Exceptional Sensitivity

September 10, 2025

In Vivo Itaconate Tracing Uncovers Degradation Kinetics

September 10, 2025

Fast Imaging Screen Finds Potent SKP2 Oncoprotein Degrader

September 10, 2025

Grid Cells Accurately Track Movement Amid Reference Switch

September 10, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Breakthrough in Computer Hardware Advances Solves Complex Optimization Challenges

    151 shares
    Share 60 Tweet 38
  • New Drug Formulation Transforms Intravenous Treatments into Rapid Injections

    116 shares
    Share 46 Tweet 29
  • Physicists Develop Visible Time Crystal for the First Time

    53 shares
    Share 21 Tweet 13
  • First Confirmed Human Mpox Clade Ib Case China

    56 shares
    Share 22 Tweet 14

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Predicting Lithium-Ion Battery Health with Charging Segments

Next-Generation Wearable Pressure Sensors Inspired by Cat Whiskers Deliver Exceptional Sensitivity

Desire vs. Ability: Unveiling a New Model to Understand Waste Separation Habits

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.