Powering a pacemaker with a patient’s heartbeat

Implantable pacemakers have without doubt altered modern medicine, saving countless lives by regulating heart rhythm. But they have one serious shortcoming: Their batteries last only five to 12 years, at which point they have to be replaced surgically. Now, researchers have surmounted this issue by designing a pacemaker powered by the energy of heartbeats, according to a report in ACS Nano. The device was successfully tested in pigs, which have a similar physiology to humans.

A conventional pacemaker is implanted just under the skin near the collarbone. Its battery and circuitry generate electrical signals that are delivered to the heart via implanted electrodes. Because surgery to replace the battery can lead to complications, including infection and bleeding, various researchers have tried to build pacemakers that use the natural energy of heartbeats as an alternative energy source. However, these experimental devices aren’t powerful enough because of their rigid structure, difficulties with miniaturization and other drawbacks, so Hao Zhang, Bin Yang and colleagues searched for ways to improve the technology.

First, they designed a small, flexible plastic frame. Next they bonded the frame to piezoelectric layers, which generate energy when bent. They implanted the device in pigs and showed that a beating heart could in fact alter the frame’s shape, generating enough power to match the performance of a battery-powered pacemaker. The study is a step toward making a self-powered cardiac pacemaker, the researchers say.

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The authors acknowledge funding from the 863 Program, the National Natural Science Foundation of China and the Natural Science Foundation of Shanghai.

The paper’s abstract will be available on Feb. 20 at 8 a.m. Eastern time here: http://pubs.acs.org/doi/abs/10.1021/acsnano.8b08567

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