Genome-wide screen in the nematode Caenorhabditis elegans reveals potential targets to delay motor aging, including the phosphatidylinositol 3-kinase VPS-34; genetic and pharmacological partial inhibition of VPS-34 improves neurotransmission and muscle integrity through increased PI(3)P-PI-PI(4)P conversion, ameliorating motor aging in both worms and mice.
Credit: Newbing AI and Dr. Yan Zhang (CC-BY 4.0, https://creativecommons.org/licenses/by/4.0/)
Genome-wide screen in the nematode Caenorhabditis elegans reveals potential targets to delay motor aging, including the phosphatidylinositol 3-kinase VPS-34; genetic and pharmacological partial inhibition of VPS-34 improves neurotransmission and muscle integrity through increased PI(3)P-PI-PI(4)P conversion, ameliorating motor aging in both worms and mice.
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In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002165
Article Title: Partial inhibition of class III PI3K VPS-34 ameliorates motor aging and prolongs health span
Author Countries: China
Funding: see manuscript
Competing interests: The authors have declared that no competing interests exist.
Journal
PLoS Biology
DOI
10.1371/journal.pbio.3002165
Article Title
Partial inhibition of class III PI3K VPS-34 ameliorates motor aging and prolongs health span
Article Publication Date
11-Jul-2023
COI Statement
The authors have declared that no competing interests exist.
